Myelin Basic Protein (68-82), guinea pig
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
髓鞘碱性蛋白(68-82),豚鼠,化学式为C71H113N23O28,序列为Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn,分子量为1736.79。髓鞘碱性蛋白(MBP)对神经系统神经髓鞘的形成具有重要作用。MBP基因敲除小鼠中,MBP基因的缺陷导致中枢神经系统(CNS)中髓鞘形成减少,形成一种进行性疾病,特征表现为震颤、抽搐和过早死亡。对MBP的研究集中在它在脱髓鞘疾病,尤其是多发性硬化(MS)中的作用。一些研究已经发现了针对MBP的抗体在MS发病机制中的作用。研究揭示MBP基因与MS的遗传易感性相关,虽然大部分都没有。近期的研究表明,接种MBP的动物产生免疫反应,增加了血脑屏障的渗透性。
Figure1 Formula of Myelin Basic Protein (68-82), guinea pig
Figure2 Structure of Myelin Basic Protein
参考文献:
1. Sakamoto Y, Kitamura K, Yoshimura K, Nishijima T, Uyemura K (March 1987). "Complete amino acid sequence of POprotein in bovine peripheral nerve myelin". J. Biol. Chem. 262 (9): 4208–14.
2. Deber CM, Reynolds SJ (April 1991). "Central nervous system myelin: structure, function, and pathology". Clin. Biochem. 24 (2): 113–34.
3. Inouye H, Kirschner DA (January 1991). "Folding and function of the myelin proteins from primary sequence data". J. Neurosci. Res. 28 (1): 1–17.
4. Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, Dilitz E, Deisenhammer F, Reindl M (July 2003). "Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event". N. Engl. J. Med. 349 (2): 139–45.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 1736.81 |
Cas No. | 98474-59-0 |
Formula | C71H113N23O28 |
Synonyms | H2N-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH |
Solubility | insoluble in EtOH; ≥173.6 mg/mL in DMSO; ≥54.6 mg/mL in H2O |
SDF | Download SDF |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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