Moxonidine
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Moxonidine是一种I1-咪唑啉受体激动剂,EC50值为1.3 M[1]。
Moxonidine可与I1-咪唑啉受体(I1R)和α2-肾上腺素能受体(α2AR)结合。Moxonidine对I1R的选择性是α2AR的33倍。Moxonidine在中枢神经系统中具有抗高血压能力。该物质有一个活性中心位点。该物质在无脊髓大鼠和切断脊髓的猫中并无效果。Moxonidine也可降低交感神经输出并减小外周血管阻力[1,2]。
除了抗高血压效果,Moxonidine对大鼠胃分泌和胃粘膜损伤也有效果。该物质剂量为0.1(63%抑制)和1.0(65%抑制)mg/kg时可显著降低基础胃酸分泌。即便0.01 mg/kg的moxonidine也能降低乙醇导致的胃粘膜损伤[3]。
参考文献:
[1] George OK, Gonzalez RR Jr, Edwards LP. Moxonidine, an antihypertensive agent, is permissive to alpha1-adrenergic receptor pathway in the rat-tail artery. J Cardiovasc Pharmacol. 2004 Feb;43(2):306-11.
[2] Morris ST, Reid JL. Moxonidine: a review. J Hum Hypertens. 1997 Oct;11(10):629-35.
[3] Glavin GB, Smyth DD. Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br J Pharmacol. 1995 Feb;114(4):751-4.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 241.68 |
Cas No. | 75438-57-2 |
Formula | C9H12ClN5O |
Solubility | insoluble in H2O; ≥11.3 mg/mL in DMSO; ≥4.74 mg/mL in EtOH with ultrasonic |
Chemical Name | 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine |
SDF | Download SDF |
Canonical SMILES | CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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