Moxifloxacin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Moxifloxacin是口服有效的广谱氟喹诺酮类抗生素,抑制细菌DNA旋转酶[1].
据报道,50 μg/mL Moxifloxacin显著减少活细胞.50-1500μg/mL 浓度范围的Moxifloxacin具有显著的抗增殖活性.此外,Moxifloxacin可以剂量依赖性地引起细胞损伤,使其出现双核之类的特征.
在大鼠中,静脉注射Moxifloxacin(100 mg/kg)增加血糖和血清肾上腺素浓度,同时促进组胺释放.然而,75 mg/kg Moxifloxacin对血清肾上腺素\葡萄糖或组胺浓度的增加无任何影响[3].
参考文献：
[1] Iatropoulos MJ1, Jeffrey AM, Enzmann HG, von Keutz E, Schlueter G, Williams GM. Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic. Exp Toxicol Pathol. 2001 Oct;53(5):345-57.
[2] Sobolewska B1, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P, Yoeruek E. Antiproliferative and cytotoxic properties of moxifloxacin on rat retinal ganglion cells. Curr Eye Res. 2013 Jun;38(6):662-9.
[3] Ishiwata Y1, Takahashi Y, Nagata M, Yasuhara M. Effects of moxifloxacin on serum glucose concentrations in rats. Biol Pharm Bull. 2013;36(4):686-90.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 401.43 |
| Cas No. | 151096-09-2 |
| Formula | C21H24FN3O4 |
| Solubility | ≥11.62 mg/mL in EtOH with gentle warming and ultrasonic; ≥25.6 mg/mL in H2O with gentle warming and ultrasonic; ≥50.8 mg/mL in DMSO with gentle warming |
| Chemical Name | 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 细胞实验 [1]： | |
|
细胞系 |
大鼠视网膜神经节细胞 |
|
溶解方法 |
在DMSO中的溶解度 ≥50.8 mg/mL。为了获得更高的浓度，可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
|
反应条件 |
5～1500 μg/mL |
|
应用 |
孵育24和72小时后，moxifloxacin浓度低于50μg/ mL时，RGC5细胞均未观察到细胞毒性或抗增殖作用。在较高浓度（150μg/ mL，500μg/ mL和1500μg/ mL）下，RGC5细胞的数量和增殖速率显着降低。 |
| 动物实验 [2]： | |
|
动物模型 |
雄性Wistar大鼠 |
|
剂量 |
75或100mg/kg（静脉注射） |
|
应用 |
当moxifloxacin为100 mg / kg时，血清葡萄糖浓度增加，并且血清肾上腺素和组胺浓度随时间升高。而静脉注射75 mg / kg的moxifloxacin不会影响血清中葡萄糖、肾上腺素或组胺的浓度。 当moxifloxacin浓度为75和100 mg / kg时，血清免疫反应性胰岛素浓度不变。 总之，moxifloxacin可诱导组胺释放，导致血清肾上腺素浓度增加和高血糖症。 |
|
注意事项 |
请测试所有化合物在室内的溶解度，实际溶解度和理论值可能略有不同，这是由实验系统的误差引起的，属于正常现象。 |
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References: [1]. Sobolewska B, Hofmann J, Spitzer MS, Bartz-Schmidt KU, Szurman P, Yoeruek E.Antiproliferative and cytotoxic properties of moxifloxacin on rat retinal ganglion cells. Curr Eye Res. 2013 Jun;38(6):662-9. doi:10.3109/02713683.2012.746991. PubMed PMID: 23654355. [2]. Ishiwata Y, Takahashi Y, Nagata M, Yasuhara M. Effects of moxifloxacin on serum glucose concentrations in rats. Biol Pharm Bull. 2013;36(4):686-90. Epub 2013 Jan 25. PubMed PMID: 23358329. |
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质量控制和MSDS
- 批次:
化学结构
