ML167
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
ML167是高选择性Cdc2样激酶4(Clk4)抑制剂,IC50值为136 nM.
Clk激酶家族通过磷酸化剪接体的主要组分SR蛋白,在基因剪接过程中发挥重要作用.靶向Clk的小分子探针用于研究这些激酶在基因剪接中的调节功能.ML167是第一个被发现的Clk4完全选择性抑制剂,而对其它相关激酶没有作用,包括Clk1\Clk2\Clk3和Dyrk1A/1B.其对Clk4的抑制效应高于其它激酶10倍.ML167处理Caco-2细胞表明,ML167具有较高的细胞渗透性.此外,ML167也是ATP竞争性抑制剂[1].
参考文献：
[1] Rosenthal A S, Tanega C, Shen M, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2011.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 335.36 |
| Cas No. | 1285702-20-6 |
| Formula | C19H17N3O3 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥16.75 mg/mL in DMSO |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | ML167是高选择性Cdc2样激酶4(Clk4)抑制剂,IC50值为136 nM. | |||||
| 靶点 | Clk4 | |||||
| IC50 | 136 nM | |||||
质量控制和MSDS
- 批次:
化学结构
