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ML167

现货
Catalog No.
B3707
Clk4抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 800.00
Ship with 10-15 days
10mg
¥ 1,160.00
现货
25mg
¥ 2,370.00
Ship with 10-15 days

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Background

ML167 is a highly selective inhibitor of Cdc2-like kinase 4 (Clk4) with IC50 value of 136nM [1].

The Clk family enzymes play their roles in gene splicing via phosphorylating the major component of the spliceosome, SR proteins. Small molecule probes that target Clk’s can be used to study the modulating functions of these kinases in gene splicing. ML167 is found as the first fully selective inhibitor of Clk4 but not other related kinases including Clk1, Clk2 and Clk3 and Dyrk1A/1B. It is 10-fold more potent against Clk4 over other kinases. The treatment of ML167 on Caco-2 cells proves that ML167 is highly cell-permeable. Besides that, ML167 is also found to be an ATP-competitive inhibitor [1].

References:
[1] Rosenthal A S, Tanega C, Shen M, et al. An inhibitor of the Cdc2-like kinase 4 (Clk4). 2011.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt335.36
Cas No.1285702-20-6
FormulaC19H17N3O3
Solubility≥16.75mg/mL in DMSO
SDFDownload SDF
Canonical SMILESCC1=CC=C(O1)CNC2=NC=NC3=C2C=C(C=C3)C4=CC=C(O4)CO
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

生物活性

Description ML167是高选择性Cdc2样激酶4(Clk4)抑制剂,IC50值为136 nM.
靶点 Clk4          
IC50 136 nM          

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