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ML-097

 
Catalog No.
C4821
Ras相关GTPase的激活剂
组合的产品项目
规格价格库存 数量
5mg
¥ 2,275.00
Ship with 10-15 days
10mg
¥ 3,304.00
Ship with 10-15 days
25mg
¥ 5,579.00
Ship with 10-15 days

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A

背景

ML-097 (CID-2160985) is a pan activator of Ras-related GTPases [1].

The Ras superfamily of GTPases, which includes Arf, Rho, Ras and Rab GTPase subfamilies, regulate many cellular processes ranging from membrane trafficking to the control of cell proliferation. Alteration of small GTPase functions is a hallmark of genetic and sporadic human diseases, making GTPase family members attractive targets. The mutated forms of small GTPases may cause disease either through aberrant activation or through loss of function or diminished acitivity [1].

ML-097 is a novel pan activator of Ras-related GTPases that activating cell division cycle 42 activated mutant, cell division cycle 42, Ras activated mutant, Ras, rab7, Rac1 activated mutant and Rac1 with EC50 values of 50, 102, 93, 109, 20, 81 and 151 nM, respectively. ML-097 is a probe compound that functions by increasing the affinity of the GTPases for guanine nucleotides [1].

Reference:
[1].  Surviladze Z, Ursu O, Miscioscia F, et al. Three small molecule pan activator families of Ras-related GTPases. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2009 May 18 [updated 2010 Sep 2].

化学属性

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt307.1
Cas No.743456-83-9
FormulaC14H11BrO3
SynonymsCID-2160985
Solubility≤5mg/ml in DMSO
Chemical Name2-[(2-bromophenyl)methoxy]-benzoic acid
SDFDownload SDF
Canonical SMILESBrC1=C(COC2=C(C(O)=O)C=CC=C2)C=CC=C1
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质量控制

质量控制和MSDS

批次:

化学结构

ML-097