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Micafungin sodium

现货
Catalog No.
A3606
1,3-β-D-葡聚糖合成抑制剂,杀菌剂。
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 1,450.00
现货
5mg
¥ 700.00
现货
10mg
¥ 1,300.00
现货
25mg
¥ 2,790.00
现货
50mg
¥ 3,900.00
现货

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Background

Micafungin is an antifungal agent [1].
Antifungal medicine is a pharmaceutical fungicide used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
Micafungin is an antifungal agent known to inhibit 1,3-β-D-glucan synthesis in Candida albicans. In 13 out of 18 P. Aeruginosa isolates tested, micafungin significantly reduced biofilm biomass. In all 9 P. Aeruginosa isolates tested, micafungin decreased the expression of ndvB, which encoded the cell wall 1,3-β-D-glucan. Also, it decreased the expression of biofilm encoding genes for alginate and pellicles (algC and pelC, respectively) [1].
In a mouse model of septic A. fumigatus infection, micafungin (0.1 mg/kg) increased the survival rate of mice to 20%. When micafungin (0.1 mg/kg) combination with KB425796-C (32 mg/kg), the survival rate of mice increased to 100% in the 31-day post-infection period. While non-treated mice survived for only 6 days [2].
References:
[1]. Bazzi W, Sabra A, Zahreddine L, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling, 2013, 29(8): 909-915.
[2]. Kai H, Yamashita M, Nakamura I, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigatus and its efficacy in murine infection models. J Antibiot (Tokyo), 2013, 66(8): 479-484.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1292.26
Cas No.208538-73-2
FormulaC56H70N9NaO23S
SynonymsFK 463;Funguard;Mycamine
Solubility≥64.66 mg/mL in DMSO, <2.35 mg/mL in EtOH, ≥17.5 mg/mL in H2O with ultrasonic and warming
SDFDownload SDF
Canonical SMILESCCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC(=C(C=C7)O)OS(=O)(=O)[O-])O)O)C(CC(=O)N)O)C)O)O)O.[Na+]
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

试验操作

真菌试验 [1]:

真菌

铜绿假单胞菌 (P. Aeruginosa)

制备方法

溶于水。若配制更高浓度的溶液,一般步骤如下:请将试管置于37℃加热10分钟和/或将其置于超声波浴中震荡一段时间。原液于-20℃可放置数月。

反应条件

10 mg/mL;24小时

实验结果

Micafungin下调海藻酸盐和菌膜相关的生物膜编码基因(分别为algC和pelC)表达。

动物实验 [2]:

动物模型

小鼠脓毒症烟曲霉菌 (A. fumigatus) 感染模型

给药剂量

0.1、0.32和1 mg/kg;皮下注射;每日1次

实验结果

在小鼠脓毒症A. fumigatus感染模型中,Micafungin (0.1 mg/kg) 使小鼠的存活率增加至20%。当Micafungin (0.1 mg/kg) 与KB425796-C (32 mg/kg) 联合用药时,于感染后的31天内,小鼠的存活率被提高至100%。对于无处理的小鼠,它们只存活了6日。

其它注意事项

请于室内测试所有化合物的溶解度。虽然化合物的实际溶解度可能与其理论值略有不同,但仍处于实验系统误差的允许范围内。

References:

[1]. Bazzi W, Sabra A, Zahreddine L, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling, 2013, 29(8): 909-915.

[2]. Kai H, Yamashita M, Nakamura I, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigatus and its efficacy in murine infection models. J Antibiot (Tokyo), 2013, 66(8): 479-484.

质量控制

化学结构

Micafungin sodium