Methazolamide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Methazolamide(醋甲唑胺)是磺酰胺的衍生物,是碳酸酐酶(CA)的抑制剂,可有效抑制CA的同工酶CAII和CAIV,IC50值分别是8.1 nM和80.3 nM。醋甲唑胺已广泛用于治疗青光眼,其通过降低碳酸氢根离子的形成,减少内眼中流体形成的速度,随后降低钠和液体的输送能力。最近的研究表明,醋甲唑胺可以作为胰岛素敏化剂,抑制肝葡萄糖生成,而其他CA抑制剂没有这种效果。
参考文献:
Konstantopoulos N, Molero JC, McGee SL, Spolding B, Connor T, de Vries M, Wanyonyi S, Fahey R, Morrison S, Swinton C, Jones S, Cooper A, Garcia-Guerra L, Foletta VC, Krippner G, Andrikopoulos S, Walder KR. Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo. Diabetes. 2012;61(8):2146-2154
Chang X, Yan X, Zhang Y. Treat ankylosing spondylitis with methazolamide. Int J Med Sci;8(5):413-419
Gudmundsdóttir E, Stefánsson E, Bjarnadóttir G, Sigurjónsdóttir JF, Gudmundsdóttir G, Masson M, Loftsson T. Methazolamide 1% in cyclodextrin solution lowers IOP in human ocular hypertension. Invest Ophthalmol Vis Sci. 2000;41(11):3552-3554.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 236.27 |
Cas No. | 554-57-4 |
Formula | C5H8N4O3S2 |
Synonyms | Naptazane, N-Methylacetazolamide |
Solubility | ≥11.18 mg/mL in EtOH with gentle warming and ultrasonic; ≥2.58 mg/mL in H2O with gentle warming and ultrasonic; ≥23.63 mg/mL in DMSO |
Chemical Name | N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide |
SDF | Download SDF |
Canonical SMILES | CC(=O)N=C1N(N=C(S1)S(=O)(=O)N)C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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