MDL 72832 hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
MDL 72832盐酸盐是一种强效的和选择性的5-HT1A受体的配体,pIC50值为9.1 [1].
5-T1A受体是一种内源性神经递质5-羟色胺(5-HT)的G蛋白偶联受体,介导抑制性神经递质.
MDL 72832盐酸盐是一种强效的和选择性的5-HT1A受体的配体[1].另外,MDL 72832对5-HT1C 和5-HT1D受体也具有亲和力,pKD值分别为6.32和6.34[1].
大鼠中,MDL 72832抑制8-OH-DPAT诱发的心血管效应.在豚鼠体内,8-OH-DPAT浓度依赖性地抑制场刺激的豚鼠回肠收缩.然而,MDL 72832抑制8-OH-DPAT诱发的神经元抑制.MDL 72832是5-HT1A受体的配体,具有拮抗剂和激动剂的混合性质[1].在未进满食的大鼠体内,(+) -MDL 72832 (1.0 mg/kg) 刺激食物摄入,(-) -MDL 72832 (0.03 mg/kg)显著增加食物摄入[2].在大鼠中,MDL 72832增加突触后5-HT1A受体介导的低温症,且其具有激动剂特性[3].
参考文献:
[1]. Mir AK, Hibert M, Tricklebank MD, et al. MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors. Eur J Pharmacol, 1988, 149(1-2): 107-120.
[2]. Neill JC, Cooper SJ. MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake. Eur J Pharmacol, 1988, 151(2): 329-332.
[3]. Millan MJ, Rivet JM, Canton H, et al. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. J Pharmacol Exp Ther, 1993, 264(3): 1364-1376.
Physical Appearance | White crystalline solid |
Storage | Store at RT |
M.Wt | 422.95 |
Cas No. | 113777-40-5 |
Formula | C22H30N2O4·HCl |
Solubility | Soluble to 5 mM in H2O |
Chemical Name | 8-(4-(((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)amino)butyl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride |
SDF | Download SDF |
Canonical SMILES | O=C(N1CCCCNCC2COC3=CC=CC=C3O2)CC4(CC1=O)CCCC4.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |