Marinopyrrole A
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Marinopyrrole A是一种选择性Mcl-1抑制剂，IC50值为10.1 μM[1]。
Marinopyrrole A是一种海洋来源的链霉菌的天然产物，是Mcl-1的拮抗剂。Mcl-1是抗凋亡Bcl-2家族的一个成员，该家族是充分验证的癌症治疗药物靶标。NMR滴定实验表明Marinopyrrole A可直接与Mcl-1相互作用。该物质可阻止Bim-BH3多肽结合Mcl-1而非Bcl-XL。基于细胞的试验显示Marinopyrrole A具有高选择性。Marinopyrrole A疗法可抑制转染Mcl-1基因的K562细胞的活力，EC50值为1.6 μM。选择性比转染Bcl-XL基因的细胞强40多倍。此外，Marinopyrrole A可通过增加caspase-3和PARP剪切，减少Mcl-1表达。Marinopyrrole A也可完全恢复多重耐药白血病细胞对ABT-737的敏感性[1]。
参考文献：
[1] Doi K, Li R, Sung SS, et al. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem. 2012 Mar, 287(13): 10224-35.
| Storage | Store at -20°C |
| M.Wt | 510.15 |
| Cas No. | 1227962-62-0 |
| Formula | C22H12Cl4N2O4 |
| Solubility | Soluble in DMSO |
| SDF | Download SDF |
| Canonical SMILES | OC1=CC=CC=C1C(C2=C(N3C(C(C4=CC=CC=C4O)=O)=CC(Cl)=C3Cl)C(Cl)=C(Cl)N2)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | Marinopyrrole A是一种选择性Mcl-1抑制剂，IC50值为10.1 μM。 | |||||
| 靶点 | Mcl-1 | |||||
| IC50 | 10.1 μM | |||||
化学结构
