MAP kinase fragment [Multiple species]

丝裂原活化蛋白激酶（MAP激酶）片段的氨基酸序列为Lys-Tyr-Ile-His-Ser-Ala-Asn-Val-Leu。

MAP激酶是丝氨酸/苏氨酸特异性蛋白激酶，属于CMGC（CDK / MAPK / GSK3 / CLK）激酶家族。

MAPK途径是由多种胞外信号激活的蛋白信号级联反应，包括生长因子、细胞因子和环境应激刺激。通过活化特定的转录因子和其它调节蛋白，激活的MAPK途径调节许多基本细胞功能，包括分化、增殖和凋亡。

MAPKs参与各种刺激诱导的细胞应答，这些刺激包括促细胞分裂剂、渗透胁迫、热休克和促炎细胞因子。MAPK蛋白反复涉及癌症和自身免疫疾病的发病机制，使它们成为药物开发的靶标。

Figure 1: x-ray of an ERK2 MAP kinase in its active form.

参考文献：

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