Malotilate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50: N/A
Malotilate（二异丙基-1,3-二硫醇-2-亚基丙二酸二乙酯）是一种新型的嗜肝药物，可提高蛋白质代谢并刺激肝细胞再生。
体外：使用大鼠肺内皮细胞（RLE）单层细胞进行的体外侵袭实验表明，使用malotilate预处理肺内皮细胞而非C-SST-2细胞，显著减少c-SST-2细胞入侵RLE单层细胞。体外血管渗透性试验还证明Malotilate还可以防止血清饥饿导致的肺内皮细胞单层细胞渗透性增加。与此相反，Malotilate治疗不影响c-SST-2细胞产生明胶酶和粘附于RLE细胞单层细胞 [1]。
体内：c-SST-2细胞s.c.接种前7天或之后第7天，同系SHR大鼠口服给药malotilate直至实验结束。与未接受处理的大鼠相比，接受Malotilate治疗的大鼠的肺转移受到显着抑制。此外，在C-SST-2细胞接种19天后接受Malotilate治疗的大鼠，肺转移也受到显著抑制[1]。
临床试验：先前的临床试验结果表明，Malotilate能加速酒精性肝病中受损蛋白质代谢的恢复，因此Malotilate对于酒精性肝病的治疗可能有效[2]。
参考文献：
[1] Nagayasu H,Hamada J,Kawano T,Konaka S,Nakata D,Shibata T,Arisue M,Hosokawa M,Takeichi N,μMoriuchi T. Inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells by modifying the functions of vascular endothelial cells. Br J Cancer.1998 May;77(9):1371-7.
[2] Takase S,μMatsuda Y,Yasuhara M,Takada A. Effects of malotilate treatment on alcoholic liver disease. Alcohol.1989 May-Jun;6(3):219-22.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 288.38 |
| Cas No. | 59937-28-9 |
| Formula | C12H16O4S2 |
| Solubility | insoluble in H2O; ≥14.419 mg/mL in DMSO; ≥25.83 mg/mL in EtOH |
| Chemical Name | dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)OC(=O)C(=C1SC=CS1)C(=O)OC(C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
