LY2409881
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
LY2409881是IKK2的强效选择性抑制剂，IC50值为30 nM[1]。
IκB激酶β（IKK2）作为IκB激酶的一个亚基，参与细胞因子活化的免疫应答反应。IKK2激活核因子kappa-B激酶（NF-κB）。
LY2409881是IKK2的选择性抑制剂，与其它普通激酶和IKK1相比，其对于IKK2的选择性大于10倍。在卵巢癌细胞系SKOV3中，LY2409881具有一定毒性。LY2409881和TNFɑ显著诱导细胞死亡，这表明LY2409881以TNFɑ依赖的方式抑制NF-κB介导的抗凋亡信号。在DLBCL细胞系LY10中，10 μM的LY2409881抑制TNFɑ依赖性的IκB磷酸化。在DLBCL细胞系SUDHL2中，10 μM的LY2409881抑制p50和NF-κB的核信号。同样地，LY2409881以浓度依赖性方式诱导细胞凋亡[1]。
在含有LY10细胞衍生肿瘤的SCID-beige小鼠中，50、100和200 mg/kg的LY2409881显著抑制肿瘤生长[1]。
参考文献：
[1]. Deng C, Lipstein M, Rodriguez R, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res, 2015, 21(1): 134-145.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 594.43 |
| Cas No. | 946518-60-1 |
| Formula | C24H32Cl4N6OS |
| Solubility | ≥59.4 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | ClC1=CN=C(NCCCN2CCN(C)CC2)N=C1C3=CC4=C(S3)C=CC=C4C(NC5CC5)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
