Luliconazole
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 354.28 |
| Cas No. | 187164-19-8 |
| Formula | C14H9Cl2N3S2 |
| Synonyms | NND 502; Lulicon |
| Solubility | insoluble in H2O; ≥17.71 mg/mL in DMSO; ≥32.53 mg/mL in EtOH with gentle warming |
| Chemical Name | (2E)-2-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile |
| SDF | Download SDF |
| Canonical SMILES | C1C(SC(=C(C#N)N2C=CN=C2)S1)C3=C(C=C(C=C3)Cl)Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 细胞实验 [1]： | |
|
细胞系 |
皮肤癣菌，接合菌，丝状真菌 |
|
溶解方法 |
在DMSO中的溶解度 ≥ 17.714 mg/mL。为了获得更高的浓度，可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
|
反应条件 |
0.004～0.008 μg/ml |
|
应用 |
研究结果表明，皮肤癣菌对Luliconazole最敏感（MIC ≤ 0.004～0.008 μg/ml），在低浓度时（MIC ≤ 0.004～0.125 μg/ml）时，Luliconazole抑制除接合菌的所有丝状真菌。 |
| 动物实验 [2]： | |
|
动物模型 |
豚鼠 |
|
剂量 |
1%乳膏 |
|
应用 |
研究结果表明：Luliconazole（1％乳膏）治疗效果略低于特比萘芬。Luliconazole处理的豚鼠有少量的分生孢子毛发。 |
|
注意事项 |
请测试所有化合物在室内的溶解度，实际溶解度和理论值可能略有不同，这是由实验系统的误差引起的，属于正常现象。 |
|
References: [1]. Uchida K, Nishiyama Y, Yamaguchi H. In vitro antifungal activity of luliconazole (NND-502), a novel imidazole antifungal agent. J Infect Chemother.2004 Aug;10(4):216-9. PubMed PMID: 15365862. [2]. Ghannoum MA, Long L, Kim HG, Cirino AJ, Miller AR, Mallefet P. Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model. Med Mycol. 2010 May;48(3):491-7. doi: 10.3109/13693780903373811. PubMed PMID: 20370362. |
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质量控制和MSDS
- 批次:
化学结构
