LH846
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
LH846是酪蛋白激酶抑制剂,对CKIδ\CKIα和CKIε的IC50值分别为290 nM\2.5 μM和1.3 μM.
LH846作为一种酪蛋白激酶的小分子抑制剂,被研发用于治疗由昼夜节律紊乱引发的相关疾病.LH846是从基于人U2OS细胞的试验中被筛选出来的,在8 μM的浓度下,能够影响昼夜节律并延长周期(10小时).LH846可以抑制CKIδ\CKIα和CKIε活性,其IC50值分别为290 nM\2.5 μM和1.3 μM.LH846的特异性靶点是CKIδ.在约50种激酶中,LH846有效抑制CKIδ,对CKIα和ROCK2抑制作用相对较弱.CK2对LH846不敏感[1].
参考文献：
[1] Lee J W, Hirota T, Peters E C, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angewandte Chemie, 2011, 123(45): 10796-10799.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 316.81 |
| Cas No. | 639052-78-1 |
| Formula | C16H13ClN2OS |
| Solubility | Soluble in DMSO |
| Chemical Name | (Z)-N-(5-chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetimidic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC(S2)=C(N=C2/N=C(O)/CC3=CC=CC=C3)C=C1Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
