Leukadherin 1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Leukadherin 1是CD11b/CD18的激活剂[1]。
CD11b/CD18是一种细胞表面粘附受体，介导免疫功能和白细胞迁移，主要在先天免疫系统的细胞中表达。
Leukadherin 1是CD11b/CD18的激活剂。Leukadherin 1增加CD11b/CD18依赖性细胞粘附到纤维蛋白原上，EC50值为4 μM[1]。Leukadherin 1还可以增加CD11b/CD18依赖性细胞粘附到其配体ICAM-1上。在K562细胞中，leukadherin 1通过形成长膜系绳，从而增加CD11b/CD18与ICAM-1的结合[2]。
在急性腹膜炎小鼠模型中，leukadherin 1显著减少40％的嗜中性粒细胞积累[1]。在MHC不匹配原位肾移植小鼠模型中，leukadherin 1减少间质性白细胞浸润、肾小球损害、新内膜增生和延长存活，从48.5%（仅CsA）延长至100%（CsA和LA1）[3]。在暴露于高氧（85％O2）的新生大鼠中，leukadherin 1减少肺部巨噬细胞和中性粒细胞浸润[4]。
参考文献：
[1]. Maiguel D, Faridi MH, Wei C, et al. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal, 2011, 4(189): ra57.
[2]. Celik E1, Faridi MH, Kumar V, et al. Agonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers. Biophys J, 2013, 105(11): 2517-2527. [3]. Khan SQ, Guo L, Cimbaluk DJ, et al. A small molecule b2 integrin agonist improves chronic kidney allograft survival by reducing leukocyte recruitment and accompanying vasculopathy. Front Med (Lausanne), 2014, 1: 45.
[4]. Jagarapu J, Kelchtermans J, Rong M, et al. Leukadherin-1 Attenuates Hyperoxia-induced Lung Injury in Neonatal Rats. Am J Respir Cell Mol Biol, 2015.
| Physical Appearance | Orange solid |
| Storage | Store at -20°C |
| M.Wt | 421.49 |
| Cas No. | 344897-95-6 |
| Formula | C22H15NO4S2 |
| Solubility | Soluble in DMSO |
| Chemical Name | (Z)-4-(5-((3-benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C(N(C1=S)CC2=CC=CC=C2)/C(S1)=C([H])/C(O3)=CC=C3C4=CC=C(C(O)=O)C=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
