[Leu5]-Enkephalin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
[Leu5]-Enkephalin, naturally present in mammalian brain, is one of the endogenous pentapeptides with morphine-like properties. [Leu5]-Enkephalin exhibits agonistic actions at both the δ- and μ-opioid receptors, with substantially greater preference for the former, but shows little effect on the κ-opioid receptor. In humans, the δ-opioid receptor is most heavily expressed in basal ganglia and neocortical regions, and associated with pain, depression, as well as learning and memory. [Leu5]-Enkephalin, along with the other endogenous pentapeptide, [Met5]-enkephalin, have been found to behave as potent, yet short-lived opiates in vivo.
References:
1. Sengul G, Watson C. Chapter 6 - Spinal Cord: Regional Anatomy, Cytoarchitecture and Chemoarchitecture. The Human Nervous System (Third Edition), 2012.
2. Peppin JF, Raffa RB. Delta opioid agonists: a concise update on potential therapeutic applications. Journal of Clinical Pharmacy and Therapeutics, 2015, 40(2): 155-166.
3. Meunier JC, Moisand C. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Letters, 1977, 77(2): 209-213.
4. DiMaio J, Nguyen TM, Lemieux C, et al. Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. Journal of Medicinal Chemistry, 1982, 25(12): 1432-1438.
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 555.63 |
| Cas No. | 58822-25-6 |
| Formula | C28H37N5O7 |
| Solubility | ≥54.6 mg/mL in H2O; ≥54.8 mg/mL in EtOH; ≥55.6 mg/mL in DMSO |
| Chemical Name | (2S,5R,14S)-14-amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C([C@@H](CC1=CC=CC=C1)NC(CNC(CNC([C@H](CC(C=C2)=CC=C2O)N)=O)=O)=O)N[C@H](C(O)=O)CC(C)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Cell experiment:[4] | |
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Cell lines |
Mouse vas deferens |
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Reaction Conditions |
11.4 nM [Leu5]-encephalin |
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Applications |
[Leu5]-Encephalin inhibited electrically stimulated contractions in mouse vas deferens, with an IC50 value of 11.4 nM. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Sengul G, Watson C. Chapter 6 - Spinal Cord: Regional Anatomy, Cytoarchitecture and Chemoarchitecture. The Human Nervous System (Third Edition), 2012. 2. Peppin JF, Raffa RB. Delta opioid agonists: a concise update on potential therapeutic applications. Journal of Clinical Pharmacy and Therapeutics, 2015, 40(2): 155-166. 3. Meunier JC, Moisand C. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Letters, 1977, 77(2): 209-213. 4. DiMaio J, Nguyen TM, Lemieux C, et al. Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. Journal of Medicinal Chemistry, 1982, 25(12): 1432-1438. |
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质量控制和MSDS
- 批次:
化学结构
![[Leu5]-Enkephalin](http://www.apexbt.com//media/diy/images/struct/B5214.png)