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Laminin (925-933)

现货
Catalog No.
A1023
细胞外基质糖蛋白
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 3,700.00
现货
1mg
¥ 400.00
现货
5mg
¥ 1,200.00
现货
10mg
¥ 2,000.00
现货
25mg
¥ 2,800.00
现货

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Background

Laminin (925-933) is a peptide(Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg) derived from residues 925-933 of the laminin B1 chain that binds to the laminin receptor.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively)

The laminin beta 1 chain has 7 structurally distinct domains, which it shares with other beta chain isomers. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

 1023_1

Figure1  Structure of Laminin

  1023_2

Figure2  Formula of LamininB1 (925-933)

Ref:

1.Ikonen J, Pikkarainen T, Savolainen ER, Tryggvason K (Feb 1989). "A Hpa I polymorphism in the human laminin B1 chain gene on 7q22". Nucleic Acids Res 17 (1): 473.

2.Roche KB, Moore JW, Surana RB, Wilson BE (May 1989). "Aortic root dilatation associated with partial trisomy 7(q31.2----qter)". Pediatr Cardiol 10 (1): 53–5.

3.Bonneau D, Huret JL, Godeau G, Couet D, Putterman M, Tanzer J, Babin P, Larregue M (Sep 1991). "Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype". Hum Genet 87 (3): 317–9. 

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Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt967.06
Cas No.110590-60-8
FormulaC40H62N12O14S
SynonymsH2N-Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-OH
Solubility≥48.35mg/mL in DMSO
Chemical NameLaminin (925-933)
SDFDownload SDF
Canonical SMILESCCC(C)C(C(=O)NCC(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)CNC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(CS)N
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

化学结构

Laminin (925-933)

相关生物数据

Laminin (925-933)

相关生物数据

Laminin (925-933)