Lamin fragment
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Lamin片段（核纤层蛋白片段）的多肽序列为Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp。
核纤层蛋白是V型中间丝，根据在细胞周期中的同源性序列、生物化学性质和细胞定位，可将其分为A型或B型，A型包括核纤层蛋白A和C，B型包括核纤层蛋白B1和B2。核纤层蛋白片段几乎涵盖了所有的α螺旋构象，由非α螺旋连接子分隔成多个α螺旋结构域，这些α螺旋结构域的氨基酸序列和长度高度保守。
核纤层蛋白是中间丝型的蛋白质，是核纤层的主要组成部分，核纤层是内核膜底层纤维状蛋白网络。核纤层蛋白也可以以弥漫性或斑点模式定位在细胞核内，在DNA复制、染色质组织、核孔复合体的空间排列、核生长以及核膜蛋白的锚固中发挥作用。
Figure 1: Lamin fragment
参考文献：
1. The Cell: A Molecular Approach, Cooper & Hausman. 5th Edition. Pg. 357
2. Ayelet Margalit, Sylvia Vlcek, Yozef Gruenbaum, Roland Foisner (2005). Breaking and Making of the Nuclear Envelope. Journal of Cellular Biochemistry 95, 454-465
3. Bruce Alberts, et al. Molecular Biology of the Cell (4th edition). Garland Science 676-677
4. Geoffrey M. Cooper, Robert E. Hausman. The Cell, A Molecular Approach (4th edition). Sinauer Associates 356-360
5. Goldman et al.(2002). "Nuclear lamins: building blocks of nuclear architecture". Genes and Development 16,533-547
6. Joanna M. Bridger, Nicole Foeger, Ian R. Kill, Harald Herrmann (2007). The Nuclear Lamina: both a structural framework and a platform for genome organization. FEBS Journal 274, 1354–1361
7. Nico Stuurman, Susanne Heins, Ueli Aebi (1998). Nuclear Lamins: Their Structure, Assembly and Interactions. Journal of Structural Biology 122, 42-46
8. Tripathi K, Muralikrishna B and Parnaik VK (2009) Differential dynamics and stability of lamin A rod domain mutants IJIB, 5(1), 1-8
9. Yozef Gruenbaum, Katherine L. Wilson, Amnon Harel, Michal Goldberg, Merav Cohen (2000). Nuclear Lamins – Structural Proteins with fundamental functions. Journal of Structural Biology129, 313-323
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1001.18 |
| Formula | C47H76N12O12 |
| Synonyms | H2N-Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp-OH |
| Solubility | ≥100.1 mg/mL in DMSO; insoluble in EtOH; ≥22 mg/mL in H2O |
| SDF | Download SDF |
| Canonical SMILES | NC(CCCCN)C(NC(C)C(NCC(NC(CCC(N)=O)C(NC(C(C)C)C(NC(C(C)C)C(NC(C(C)O)C(NC(C(C)CC)C(NC(CC1=CNC2=C1C=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
