KJ Pyr 9
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Target: MYC
Kd value: 6.5 ± 1.0 nM
KJ Pyr 9 is a novel small molecule inhibitor of MYC, with the Kd value of 6.5 ± 1.0 nM. Besides, KJ Pyr 9 also suppresses the formation of MYC-MAX and oncogenic transformation induced by MYC in cell culture [1].
In Vitro: In chicken embryo fibroblasts, KJ Pyr 9 was found to have the ability to interfere with the oncogenic activity of MYC, with the best aqueous solubility. Besides, in human B-cell line P493-6, 20 μM KJ Pyr 9 could significantly inhibit cell proliferation, and KJ Pyr 9 could also inhibit the proliferation of NCI-H460, MDA-MB-231, and SUM-159PT cell lines, with the IC50 values between 5-10 μM. Furthermore, treatment of P493-6 cells with KJ Pyr 9 could significantly suppress the transcription ability of MYC [1].
In Vivo: KJ Pyr 9 was found to have no acute toxicity in mouse and rat at a dose of 10 mg/kg, with an impressive ability to cross the blood-brain barrier. Besides, in a MDA-MB-231 cells xenograft tumor nude mice model, intraperitoneal injection with 10 mg/kg KJ Pyr 9 for 31 days could significantly inhibit tumor growth, while having no effect on the body weight [1].
Clinical trial: No data available recently.
Reference:
[1] Hart J R, Garner A L, Yu J, et al. Inhibitor of MYC identified in a Kröhnke pyridine library[J]. Proceedings of the National Academy of Sciences, 2014, 111(34): 12556-12561.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 385.4 |
Cas No. | 581073-80-5 |
Formula | C22H15N3O4 |
Solubility | ≤20mg/ml in DMSO;25mg/ml in dimethyl formamide |
Chemical Name | 4-[2-(2-furanyl)-6-(4-nitrophenyl)-4-pyridinyl]-benzamide |
SDF | Download SDF |
Canonical SMILES | NC(C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
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