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Kif15-IN-2

现货
Catalog No.
B3281
有效的Kif15驱动蛋白抑制剂
组合的产品项目
规格价格库存 数量
2mg
¥ 2,600.00
现货
5mg
¥ 3,910.00
现货
10mg
¥ 5,580.00
Ship with 10-15 days
50mg
¥ 16,740.00
Ship with 10-15 days
100mg
¥ 23,440.00
Ship with 10-15 days

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Background

Kif15-IN-2, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].

Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintainingbipolar microtubulespindle apparatusin dividing cells and shares redundant functions withKIF11 [3].

References:
[1]. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2].  Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3].  Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt440.48
Cas No.672926-33-9
FormulaC20H20N6O4S
SolubilitySoluble in DMSO
Chemical Name(S,Z)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methyl-N-(4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)thiazol-2-yl)butanimidic acid
SDFDownload SDF
Canonical SMILESCC([C@@](N1C(C2=CC=CC=C2N=C1O)=O)([H])/C(O)=N/C3=NC(C)=C(S3)C4=NN=C(O4)C)C
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

质量控制和MSDS

批次:

化学结构

Kif15-IN-2