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Kif15-IN-1

现货
Catalog No.
B3280
有效的Kif15驱动蛋白抑制剂
组合的产品项目
规格价格库存 数量
2mg
¥ 2,600.00
Ship with 10-15 days
5mg
¥ 3,910.00
Ship with 10-15 days
10mg
¥ 5,580.00
Ship with 10-15 days
50mg
¥ 16,740.00
Ship with 10-15 days
100mg
¥ 23,440.00
Ship with 10-15 days

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Background

Kif15-IN-1, a potent Kif15 kinesin inhibitor; inhibits cellular proliferation in various tumor cell lines [1].

Kif15,also known as Kinesin-12 and HKLP2, is a motor protein expressed in all cells during mitosis and in postmitotic neurons undergoing axon growth [2]. Kif15 is a kinesin-related protein whose mitotic homologues are believed to crosslink and immobilize spindle microtubules.KIF15 is involved in maintaining bipolar microtubulespindle apparatusin dividing cells and shares redundant functions with KIF11 [3].

References:
[1]. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.
[2].  Buster D W, Baird D H, Yu W, et al. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development[J]. Journal of neurocytology, 2003, 32(1): 79-96.
[3].  Vanneste D, Takagi M, Imamoto N, et al. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity[J]. Current Biology, 2009, 19(20): 1712-1717.

文献引用

1. Milic B, Chakraborty A, et al. "KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics." Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4613-E4622. PMID:29703754

Chemical Properties

StorageStore at -20°C
M.Wt430.48
Cas No.672926-32-8
FormulaC20H22N4O5S
SolubilitySoluble in DMSO
Chemical Name(S,Z)-N-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)-2-(2-hydroxy-4-oxoquinazolin-3(4H)-yl)-3-methylbutanimidic acid
SDFDownload SDF
Canonical SMILESCCOC(C(S1)=C(N=C1/N=C(O)/[C@](N2C(C3=CC=CC=C3N=C2O)=O)([H])C(C)C)C)=O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

质量控制和MSDS

批次:

化学结构

Kif15-IN-1

相关生物数据

CORM-3