Ketanserin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 395.43 |
| Cas No. | 74050-98-9 |
| Formula | C22H22FN3O3 |
| Solubility | ≥39.5 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCN3C(=O)C4=CC=CC=C4NC3=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Cell experiment:[1] | |
|
Cell lines |
Isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins |
|
Reaction Conditions |
30 min incubation |
|
Applications |
Ketanserin dose-dependently inhibited contractile responses to 5-hydroxytryptamine (5-HT) in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic (threshold 10-10 ~ 10-9 M) and saphenous veins (threshold 10-8 M). |
| Animal experiment:[2] | |
|
Animal models |
Spontaneously hypertensive rats, 180 ~ 240 g |
|
Dosage form |
10 mg/kg/d Administered orally for 5 months |
|
Applications |
Ketanserin significantly decreased blood pressure and blood pressure variability, ameliorated impaired arterial baroreflex function, and significantly prevented the target organs of spontaneously hypertensive rats from being damaged. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Van Nueten JM, Janssen PA, Van Beek J, et al. Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors. Journal of Pharmacology and Experimental Therapeutics, 1981, 218(1): 217-230. 2. Du WM, Miao CY, Liu JG, et al. Effects of long-term treatment with ketanserin on blood pressure variability and end-organ damage in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 2003, 41(2): 233-239. |
|
质量控制和MSDS
- 批次:
化学结构
