KB-R7943 mesylate
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
KB-R7943 mesylate是Na+ / Ca2+交换（NCE）的有效选择性抑制剂，IC50值为0.7 μM。
NCE是一个逆向转运膜蛋白，交换3个Na+ 和一个Ca2+，根据膜两侧离子的浓度和膜电位，可以引起Ca2+积累或Ca2+排出，Ca2+积累是一种反向模式，Ca2+排出是正向模式[1]。
在表达NCE 的转染中国仓鼠卵巢细胞（CHO）中，在140 mM 胞内高钠条件下，10 μM 的KB-R7943抑制NCX活性，在10 mM 胞内低钠下没有抑制作用[2]。
在培养的大鼠前脑神经元中，使用3 μM的 glutamate，30 μM的NMDA（N-methyl-D-aspartate），100 μM 的kainite或50 mM 的KCl可以诱导[Ca2+]瞬变，KBR 7943抑制这些瞬变，IC50分别值为6.6、8.2、5.2和2.9 μM。KB-R7943不能抑制谷氨酸诱导的神经元损伤[1]。在缺血性急性肾功能衰竭（ARF）的小鼠中，KB-R7943显著降低肾脏中的内皮素-1（ET-1），缓解ARF诱导的肾功能障碍[3]。
参考文献：
[1]. Hoyt KR, Arden SR, Aizenman E, et al. Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons. Mol Pharmacol, 1998, 53(4): 742-749.
[2]. Condrescu M, Reeves JP. Inhibition of sodium-calcium exchange by KB-R7943: Dodecylamine and sphingosine in transfected Chinese hamster ovary cells. Cell Calcium, 2010, 47(5): 404-411.
[3]. Yamashita J, Ogata M, Takaoka M, et al. KB-R7943, a selective Na+/Ca2+ exchange inhibitor, protects against ischemic acute renal failure in mice by inhibiting renal endothelin-1 overproduction. J Cardiovasc Pharmacol, 2001, 37(3): 271-279.
| Storage | Store at -20°C |
| M.Wt | 427.5 |
| Cas No. | 182004-65-5 |
| Formula | C17H21N3O6S2 |
| Synonyms | KB-R7943; KB-R 7943 |
| Solubility | ≥42.8 mg/mL in DMSO; insoluble in H2O; ≥4.61 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | methanesulfonic acid;2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate |
| SDF | Download SDF |
| Canonical SMILES | CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
