JNJ-1661010
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
JNJ-1661010是一种哌嗪基苯基脲，其结构不同于烷基氨基甲酸酯和α-酮杂环化合物，是脂肪酸酰胺水解酶（FAAH）的有效选择性抑制剂，它与FAAH的活性位点共价结合，通过切割尿素功能性生成苯胺和FAAH-哌嗪氨基甲酸酯。JNJ-1661010对FAAH的抑制是可逆的，通过水解氨基甲酸酯引起哌嗪基片段的释放和FAAH酶的功能恢复。研究结果表明，JNJ-1661010可以抑制重组的FAAH，在大鼠和人中IC50值分别是10 nM和12 nM。
参考文献：
Karbarz MJ, Luo L, Chang L, Tham CS, Palmer JA, Wilson SJ, Wennerholm ML, Brown SM, Scott BP, Apodaca RL, Keith JM, Wu J, Breitenbucher JG, Chaplan SR, Webb M. Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg. 2009;108(1):316-329.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 365.45 |
| Cas No. | 681136-29-8 |
| Formula | C19H19N5OS |
| Synonyms | JNJ 1661010,JNJ1661010 |
| Solubility | Soluble in DMSO |
| Chemical Name | N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCN1C2=NC(=NS2)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | JNJ-1661010是FAAH的选择性抑制剂，在人和大鼠中的IC50值分别是33 nM和34 nM。 | |||||
| 靶点 | FAAH | FAAH | ||||
| IC50 | 33 nM (human) | 34 nM (rat) | ||||
化学结构
