Jingzhaotoxin III
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Jingzhaotoxin III是一种选择性的Nav1.5通道阻断剂，IC50值为0.348 μM[1]。Nav1.5是一种电压门控钠通道，主要在心肌细胞中表达，对心脏的电生理活动起着重要的调控作用。异常的Nav1.5通道活性与多种心脏疾病，如心律失常、心肌梗死等有关。
在细胞水平上，Jingzhaotoxin III能有效阻断Nav1.5通道的活性，从而影响心肌细胞的电生理活动。研究发现，Jingzhaotoxin III对Nav1.5通道的阻断作用具有剂量依赖性，当浓度达到1.03 μM时，可以完全阻断Nav1.5通道的活性[2]。此外，Jingzhaotoxin III对Nav1.5通道的阻断作用具有快速性和可逆性，这使得其在临床应用中具有潜在的优势。
在动物模型中，Jingzhaotoxin III的应用可以有效改善心律失常的症状。在一项对小鼠心律失常模型的研究中，通过给予Jingzhaotoxin III治疗，可以显著降低小鼠的心律失常发作频率和严重程度[2]。这些研究结果表明，Jingzhaotoxin III作为Nav1.5通道阻断剂，具有很好的抗心律失常效果，为其在心律失常等心脏疾病的治疗中的应用提供了理论依据。
参考文献
1. Rong M, et, al. Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 2011 Sep; 25(9): 3177-85.
2.Xiao Y, et al. The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation. Mol Pharmacol. 2010 Dec;78(6):1124-34.
| Physical Appearance | White lyophilised solid |
| Storage | Store at -20°C |
| M.Wt | 3919.47 |
| Cas No. | 925463-91-8 |
| Formula | C174H241N47O46S6 |
| Solubility | Soluble to 1 mg/ml in H2O |
| Chemical Name | 1-((1Z,4Z,7Z,10Z)-9-(2-carboxyethyl)-1,4,7,10-tetrahydroxy-6-isopropyl-3,12-dimethyl-1-((12E,15E,18E,21E,24Z,27Z,30Z,33Z,36Z,39Z,42E,50E,53E,56E,59E,62E,65Z,68Z,71Z,74Z,77Z,80Z,83Z,91E,93Z)-29,32,76,82-tetrakis((1H-indol-3-yl)methyl)-44-((E)-(2-((Z)-(2-(( |
| SDF | Download SDF |
| Canonical SMILES | CC(C(/N=C(O)/C(/N=C(O)/C1CSSCC(N=C(O)C2CCCN2C(C3CCCN34)=O)/C(O)=N/C(/C(O)=N/C(/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/5)C)CC6=CC=C(O)C=C6)CCCCN)CSSCC(/N=C(O)\C(/N=C(O)/C/N=C(O)/C(N)CC(O)=O)CCC(O)=O)/C(O)=N\C/C(O)=N/C/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C(O)=N/C(/C |
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