IWP-L6
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IWP-L6是一种Porcupine抑制剂,IC50值为0.5 nM[1].
IWP-L6作为Porcupine亚纳摩尔的抑制剂被开发,靶向Wnt信号通路,Porcupine是催化Wnt 蛋白棕榈酰化的酶.在HEK293细胞中,IWP-L6被发现可显著抑制dishevelled 2(Dvl2)的磷酸化.IWP-L6在人血浆中具有很好的稳定性,但在大鼠和小鼠血浆中的稳定性较弱.斑马鱼体内试验显示IWP-L6迅速活化.IWP-L6有效地阻断尾鳍的再生.IWP-L6在低微摩尔浓度下也可抑制后轴的形成.此外,在培养的小鼠胚肾中,浓度为10 nM的IWP-L6可以显著地减少分支形态发生,而浓度为50 nM的IWP-L6可完全阻断Wnt信号通路[1].
参考文献：
[1] Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56(6):2700-4.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 472.58 |
| Cas No. | 1427782-89-5 |
| Formula | C25H20N4O2S2 |
| Solubility | ≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | C1CSC2=C1N=C(N(C2=O)C3=CC=CC=C3)SCC(=O)NC4=NC=C(C=C4)C5=CC=CC=C5 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| Description | IWP-L6是一种高效的Porcupine抑制剂,EC50值为0.5 nM. | |||||
| 靶点 | Porcn | |||||
| IC50 | 0.5 nM(EC50) | |||||
质量控制和MSDS
- 批次:
化学结构
