Ivachtin
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ivachtin是Caspase-3的有效抑制剂，IC50值为23 nM[1]。
Caspase-3是半胱氨酸天冬氨酸蛋白酶家族的成员，可与caspase-8和caspase-9相互作用。Caspases的顺序激活在细胞凋亡中起重要作用。
Ivachtin以非竞争性方式强效可逆的抑制caspase-3。Ivachtin是Caspase-3最有效的抑制剂，但对于剩余的其他caspases选择性较为适中。在用10 μM的星形孢菌素(staurosporin)处理的人Jurkat T细胞中，Ivachtin可在更高的水平保护细胞，这表明，Ivachtin具有良好的细胞渗透性和抗凋亡活性[1]。
参考文献：
[1]. Kravchenko DV, Kuzovkova YA, Kysil VM, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem, 2005, 48(11): 3680-3683.
| Physical Appearance | A crystalline solid |
| Storage | Desiccate at 4°C |
| M.Wt | 447.46 |
| Cas No. | 745046-84-8 |
| Formula | C20H21N3O7S |
| Solubility | Limited solubility, soluble in DMSO or DMF |
| Chemical Name | 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate |
| SDF | Download SDF |
| Canonical SMILES | CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
