ITD 1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
TGFβ信号对心脏发育的早期阶段具有重要作用,早期的研究主要集中于其在心脏垫层形成期间的作用.这些垫层在小鼠胚胎E9.5和E11.5期间发育,是成熟瓣膜的基本前体,密切参与分隔作用.TGFβ信号促进内皮至间质的转变以及随后间充质细胞迁移到心胶质.ITD-1是TGFβ的第一个选择性抑制剂.
体外实验:ITD-1已经被用于评估TGFβ参与中胚层形成和心脏修复分化,它们在早期发育期间顺序发生,表明ESC培养中TGFβ在这两个过程中起重要作用.ITD-1选择性地增强不受约束的中胚层分化成心肌细胞,而非血管平滑肌和内皮细胞.总之,ITD-1是TGFβ的第一个选择性抑制剂,揭示了TGFβ信号在控制从多能心血管前体分化成心肌细胞的意想不到的作用[1].
在体实验:到目前为止,没有进行ITD-1的动物在体研究.
临床试验:截至目前,ITD-1仍处于临床前开发阶段.
参考文献：
[1] Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 3;11(2):242-52.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 560.67 |
| Cas No. | 1099644-42-4 |
| Formula | C29H32N6O4S |
| Solubility | ≥28.05 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | (Z)-1-(5-(tert-butyl)isoxazol-3(2H)-ylidene)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C1=C/C(NO1)=N/C(NC2=CC=C(C3=CN(C4=N3)C5=C(S4)C=C(OCCN6CCOCC6)C=C5)C=C2)=O)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
