Ionomycin free acid
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Ionomycin是一种选择性的和强效的钙离子载体,作为能动Ca2+载体。通过刺激储存调节的阳离子跨生物膜进入,ionomycin可以有效地提高Ca2+内流。
体外:Ionomycin可从液相提取钙离子进入有机相。Ionomycin还作为移动离子载体,转运阳离子穿过溶剂屏障[1]。
体内:评价Ionomycin对卵母细胞活化和随后发育的效率,确定10 μmol/l浓度下的ionomycin为有效激活剂。囊胚发育时第二次暴露于5 μmol/l的ionomycin,发现作用改善。未确定ionomycin对小鼠胚胎发育的不良影响[2]。
临床试验:在卵巢储备功能下降患者中进行一项随机、前瞻性对照研究,以分析钙离子载体液对受精率的影响,其中未观察到不同组之间受精率、临床妊娠率或继续妊娠率的任何差异[3]。
参考文献:
[1] Liu C, Hermann TE. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.
[2] Heytens E, Soleimani R, Lierman S, De Meester S, Gerris J, Dhont M, Van der Elst J, De Sutter P. Effect of ionomycin on oocyte activation and embryo development in mouse. Reprod Biomed Online. 2008 Dec;17(6):764-71.
[3] Caglar Aytac P, Kilicdag EB, Haydardedeoglu B, Simsek E, Cok T, Parlakgumus HA. Can calcium ionophore "use" in patients with diminished ovarian reserve increase fertilization and pregnancy rates A randomized, controlled study. Fertil Steril. 2015 Nov;104(5):1168-74.
Physical Appearance | A solution in ethanol |
Storage | Desiccate at -20°C |
M.Wt | 709.01 |
Cas No. | 56092-81-0 |
Formula | C41H72O9 |
Solubility | Soluble in ethanol or DMSO |
Chemical Name | (4R,6R,8R,10E,12S,14S,16E,18S,19S,20R,21S)-11,19,21-trihydroxy-22-((2R,2'R,5R,5'R)-5'-((R)-1-hydroxyethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid |
SDF | Download SDF |
Canonical SMILES | O[C@H](C)[C@]1(C)O[C@H](CC1)[C@]2(C)O[C@@H](C[C@@H]([C@@H](C)[C@H]([C@H](/C=C/C[C@H](C)C[C@H](C)/C(O)=C\C([C@H](C)C[C@H](C)C[C@H](C)CCC(O)=O)=O)C)O)O)CC2 |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |