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Ionomycin free acid

现货
Catalog No.
B6947
钙离子载体
组合的产品项目
规格价格库存 数量
1mg
¥ 1,890.00
Ship with 10-15 days

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Background

Ionomycin is a selective and potent calcium ionophore, which acts as a motile Ca2+ carrier.by direct stimulation of store-regulated cation entry across biological membranes, ionomycin can effectively enhance Ca2+ influx.

In vitro: Calcium ion can be extracted by ionomycin fom the queous phase into the organic phase. Ionomycin also acts as a mobile ion carrier, which transports the cation across a solvent barrier [1].

In vivo: Efficiency of ionomycin on oocyte activation and subsequent development was evaluated, which identified ionomycin as an efficient activator at the concentation of 10 μmol/l. With a second exposure to 5 μmol/l ionomycin on blastocyst development, an improved effect was found. No adverse effects of ionomycin on mouse embryo development were identified [2].

Clinical trial: One randomized, prospective, controlled study has been performed to analyze the effect of calcium ionophore solution on fertilization rate in patients with diminished ovarian reserve, which did not observe any differences in fertilization, clinical pregnancy, or ongoing pregnancy rates between the groups [3].

References:
[1] Liu C, Hermann TE.  Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4.
[2] Heytens E, Soleimani R, Lierman S, De Meester S, Gerris J, Dhont M, Van der Elst J, De Sutter P.  Effect of ionomycin on oocyte activation and embryo development in mouse. Reprod Biomed Online. 2008 Dec;17(6):764-71.
[3] Caglar Aytac P, Kilicdag EB, Haydardedeoglu B, Simsek E, Cok T, Parlakgumus HA.  Can calcium ionophore "use" in patients with diminished ovarian reserve increase fertilization and pregnancy rates A randomized, controlled study. Fertil Steril. 2015 Nov;104(5):1168-74.

Chemical Properties

Physical AppearanceA solution in ethanol
StorageDesiccate at -20°C
M.Wt709.01
Cas No.56092-81-0
FormulaC41H72O9
SolubilitySoluble in ethanol or DMSO
Chemical Name(4R,6R,8R,10E,12S,14S,16E,18S,19S,20R,21S)-11,19,21-trihydroxy-22-((2R,2'R,5R,5'R)-5'-((R)-1-hydroxyethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoic acid
SDFDownload SDF
Canonical SMILESO[C@H](C)[C@]1(C)O[C@H](CC1)[C@]2(C)O[C@@H](C[C@@H]([C@@H](C)[C@H]([C@H](/C=C/C[C@H](C)C[C@H](C)/C(O)=C\C([C@H](C)C[C@H](C)C[C@H](C)CCC(O)=O)=O)C)O)O)CC2
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

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化学结构

Ionomycin free acid