3-aminobenzamide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
3-Aminobenzamide (PARP-IN-1)是一种有效的 PARP 抑制剂，在CHO细胞中，对PARP的IC50值约为50nM，并在再灌注过程中充当氧化剂诱导的心肌细胞功能障碍的介质。
3-Aminobenzamide (PARP-IN-1) (>1 μM)对95%以上PARP活性有抑制作用，但没有明显的细胞毒性。3-Aminobenzamide在暴露于400μM H2O2后通过增强乙酰胆碱诱导的内皮依赖性一氧化氮介导的血管舒张作用显着改善内皮功能[1]。
在db/db（Leprdb / db）小鼠模型中，3-Aminobenzamide改善了糖尿病引起的白蛋白排泄和肾小球系膜扩张，并减少了糖尿病引起的足细胞消耗[2]。
[1]. Radovits T, et al. Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564(1-3):158-66.
[2]. Szabo C, et al. Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55(11):3004-12.
2. Waldman M, Nudelman V, et al. "PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis." Exp Cell Res. 2018 Oct 23. pii: S0014-4827(18)31064-4. PMID:30359575
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 136.15 |
| Cas No. | 3544-24-9 |
| Formula | C7H8N2O |
| Synonyms | PARP-IN-1 |
| Solubility | ≥23.45 mg/mL in H2O with ultrasonic; ≥48.1 mg/mL in EtOH with ultrasonic; ≥7.35 mg/mL in DMSO |
| Chemical Name | 3-aminobenzamide |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC(=C1)N)C(=O)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 3-aminobenzamide is a potent inhibitor of PARP with IC50 of <50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion. Phase 2. | ||||||
| Targets | PARP | |||||
| IC50 | 50 nM | |||||
质量控制和MSDS
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化学结构
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