切换导航
关闭
  • 菜单
  • Setting

immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]

 
Catalog No.
A1072
免疫球蛋白轻链片段
组合的产品项目
规格价格库存 数量
1mg
¥ 454.00
现货
5mg
¥ 1,363.00
现货
10mg
¥ 2,272.00
现货
25mg
¥ 3,181.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

免疫球蛋白轻链可变区片段序列为Leu-Leu-Ile-Tyr-Trp-Ala-Ser-Thr-Arg,是人和小鼠免疫球蛋白轻链的可变区片段。

免疫球蛋白(Ig)是B细胞的抗原识别分子。Ig分子是由2条相同的重链和2条相同的轻链通过二硫键连接,每条重链与轻链连接,2条重链连接在一起。每个轻链的均有一个可变区和恒定区。可变区的作用是结合抗原。

一条重链的和一条轻链的可变区组成抗体的抗原结合位点。典型的轻链的可变区包括105到110个氨基酸,某些位点表现出较多的序列可变性。可变片段是对IgG和IgM类抗体进行酶裂解所得到的最小片段。

A1072_1 

Figure 1: Immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]

参考文献:

1.  Janeway CA, Jr et al. (2001). Immunobiology. (5th ed.). Garland Publishing. ISBN 0-8153-3642-X

2.  Woof J, Burton D (2004). “Human antibody-Fc receptor interactions illuminated by crystal structures”. Nat Rev Immunol 4 (2): 89–99. doi :10.1038/nri1266. PMID 15040582.

3.  Mattu T, Pleass R, Willis A, Kilian M, Wormald M, Lellouch A, Rudd P, Woof J, Dwek R (1998). “The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions”. J Biol Chem 273 (4): 2260–72. doi:10.1074/jbc.273.4.2260. PMID 9442070.

4.  Roux K (1999). “Immunoglobulin structure and function as revealed by electron microscopy”. Int Arch Allergy Immunol 120 (2): 85–99. doi :10.1159/000024226. PMID 10545762.

5.  Barclay A (2003). “Membrane proteins with immunoglobulin-like domains–a master superfamily of interaction molecules”. Semin Immunol 15 (4): 215–23. doi :10.1016/S1044-5323(03)00047-2. PMID 14690046 .

6.  Putnam FW, Liu YS, Low TL (1979). “Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain”. J Biol Chem 254 (8): 2865–74. PMID 107164.

7.  Huber R (1980). “Spatial structure of immunoglobulin molecules”. Klin Wochenschr 58 (22): 1217–31. doi :10.1007/ BF01478928 6780722.

 

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt1122.32
FormulaC54H83N13O13
SynonymsH2N-Leu-Leu-Ile-Tyr-Trp-Ala-Ser-Thr-Arg-OH
Solubility≥112.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
SDFDownload SDF
Canonical SMILESNC(CC(C)C)C(NC(CC(C)C)C(NC(C(C)CC)C(NC(CC1=CC=C(O)C=C1)C(NC(CC2=CNC3=C2C=CC=C3)C(NC(C)C(NC(CO)C(NC(C(O)C)C(NC(CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制