Imiquimod hydrochloride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 276.76 |
Cas No. | 99011-78-6 |
Formula | C14H17ClN4 |
Solubility | ≥3.59 mg/mL in EtOH with ultrasonic; ≥5.54 mg/mL in DMSO with gentle warming and ultrasonic; ≥7.34 mg/mL in H2O with ultrasonic |
Chemical Name | 1-isobutyl-1H-imidazo[4,5-c]quinolin-4(5H)-imine hydrochloride |
SDF | Download SDF |
Canonical SMILES | CC(CN1C=NC2=C1C3=CC=CC=C3NC2=N)C.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Cell experiment:[1] | |
Cell lines |
Thioglycollate-elicited peritoneal cells from wild-type (C57BL/6) and MyD88-deficient mice |
Reaction Conditions |
101 ~ 104 nM imiquimod for 24 h incubation |
Applications |
Imiquimod increased TNF-α and IL-12p40 production in IFN-γ-treated murine peritoneal macrophages in a concentration- and MyD88-dependent manner. |
Animal experiment:[2] | |
Animal models |
Female Hartley guinea pigs, 400 ~ 500 g |
Dosage form |
5 mg/kg Administered intravaginally every 12 h for five days beginning 12 h after genital HSV-2 inoculation |
Applications |
Imiquimod (5 mg/kg, intravaginally, twice daily) reduced vaginal viral titer and lesion formation in a guinea pig model of genital HSV-2 infection. Imiquimod exhibited potent anti-HSV activity in vivo due to cytokine induction and enhancement of cell-mediated responses. |
Note |
The technical data provided above is for reference only. |
References: 1. Hemmi H, Kaisho T, Takeuchi O, et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nature Immunology, 2002, 3(2): 196-200. 2. Harrison CJ, Jenski L, Voychehovski T, et al. Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection. Antiviral Research, 1988, 10(4-5): 209-223. |
质量控制和MSDS
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