IC-87114
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC-87114是PI3Kδ的选择性抑制剂，IC50值0.5 μM。
据报道，IC87114减少中性粒细胞中FMLP-诱导的PIP3的合成和趋化作用[1]。IC87114也阻止了TNF1α-刺激的炎症小鼠模型中弹性蛋白酶从中性粒细胞往胞外的分泌。IC87114处理TNFα诱导的PI3Kδ信号细胞会导致Akt-磷酸化和PDK1酶活性的降低[2]。在人类记忆T细胞中，IC87114会很大程度上抑制T细胞受体诱导的原始或者效应的PI3K信号。在健康人、过敏的捐助者或类风湿性关节炎病人中IC87114可阻止记忆T细胞中产生细胞因子[3]。
参考文献：
[1]. Workman P, van Montfort RL. PI(3) kinases: revealing the delta lady. Nat Chem Biol. 2010 Feb;6(2):82-3.
[2]. Puri KD, Doggett TA, Douangpanya J, Hou Y, Tino WT, Wilson T, Graf T, Clayton E, Turner M, Hayflick JS, Diacovo TG. Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Blood. 2004 May 1;103(9):3448-56.
[3]. Soond DR, Bjrgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JS, Taskén K, Bunyard P, Okkenhaug K. PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Blood. 2010 Mar 18;115(11):2203-13.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 397.43 |
| Cas No. | 371242-69-2 |
| Formula | C22H19N7O |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥6.62 mg/mL in DMF |
| Chemical Name | 2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one |
| SDF | Download SDF |
| Canonical SMILES | CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C4N=CN=C5N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
| 描述 | IC-87114是PI3Kδ的选择性抑制剂，IC50值0.5 μM。 | |||||
| 靶点 | PI3Kδ | PI3Kγ | PI3Kβ | |||
| IC50 | 0.5 μM | 29 μM | 75 μM | |||
化学结构
