切换导航
关闭
  • 菜单
  • Setting

I-BET 151 hydrochloride

 
Catalog No.
B5670
BET bromodomain抑制剂
组合的产品项目
规格价格库存 数量
5mg
¥ 872.00
现货
10mg
¥ 1,090.00
现货
50mg
¥ 3,272.00
现货
100mg
¥ 5,727.00
现货

电话: 021-55669583

邮箱: sales@apexbio.cn

全球经销商

A

背景

I-BET 151 dihydrochloride is a bET bromodomain inhibitor that prevents BET from recruiting to chromatin. I-BET 151 induces MLL-fusion leukemia cell line apoptosis and G0 / G1 cell cycle arrest in vitro, and reduces BCL2 expression in NOMO1 cells. I-BET 151 improves the survival rate of two kinds of MLL fusion leukemia mice, and enhances the differentiation of human iPSCs into megakaryocytes.

Reference:

[1]. Malherbe P, Masciadri R, Norcross R D, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. British journal of pharmacology, 2008, 154(4): 797.

文献引用

1. Ramallo IA, Alonso VL, et al. "A Bioactive Trypanosoma cruzi Bromodomain Inhibitor from Chemically Engineered Extracts." ACS Comb Sci.2018 Apr 9;20(4):220-228. PMID:29481050

化学属性

Physical AppearanceA solid
StorageStore at -20°C
M.Wt451.9
Cas No.1883545-47-8
FormulaC23H21N5O3·HCl
Solubilityinsoluble in H2O; ≥22.05 mg/mL in EtOH; ≥31.7 mg/mL in DMSO
Chemical Name7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-((R)-1-(pyridin-2-yl)ethyl)-1H-imidazo[4,5-c]quinolin-2-ol hydrochloride
SDFDownload SDF
Canonical SMILESCC1=NOC(C)=C1C2=CC3=NC=C(N=C(O)N4[C@](C5=CC=CC=N5)([H])C)C4=C3C=C2OC.Cl
运输条件 蓝冰运输或根据您的需求运输。
一般建议不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

质量控制