HPGDS inhibitor 1
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
HPGDS inhibitor 1是一种口服有效的造血前列腺素D合成酶(HPGDS)选择性抑制剂,IC50值为0.7 nM[1]。
前列腺素D2(PGD2)是一种过敏反应和炎症调控子。该物质由PGDS异构化PGH2而来。这一产物对气管过敏反应和炎症过程十分重要。HPGDS inhibitor 1具有一个3-氟取代基,使之在体外人微粒体试验中稳定。该物质在酶试验和细胞试验中有效,IC50值分别为0.7 nM和32 nM。此外,其对从多个物种中纯化的HPGDS均有效果,IC50值从0.5到2.3 nM。除此之外,与包括L-PGDS、mPGES、COX-1、COX-2和5 LOX在内的其他相关的人类酶相比,HPGDS inhibitor 1对HPGDS具有选择性[1]。
在过敏绵羊中抗原诱导的气道反应模型中,使用HPGDS inhibitor 1可完全防止后期哮喘反应,并能阻止气道高反应性的发生[1]。
参考文献:
[1] Carron C P, Trujillo J I, Olson K L, et al. Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS). ACS Medicinal Chemistry Letters, 2010, 1(2): 59-63.
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 381.37 |
Cas No. | 1033836-12-2 |
Formula | C19H19F4N3O |
Solubility | Soluble in DMSO |
Chemical Name | 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyridine-3-carboxamide |
SDF | Download SDF |
Canonical SMILES | C1CN(CCC1NC(=O)C2=CN=C(C=C2)C3=CC(=CC=C3)F)CC(F)(F)F |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |