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HOBt (anhydrous)

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Catalog No.
A7025
外消旋抑制剂
组合的产品项目
规格价格库存 数量
100g
¥ 600.00
现货
250g
¥ 1,200.00
现货
500g
¥ 1,950.00
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Background

Hydroxy benzotriazole, abbreviated HOBt, is anorganic compoundthat is a derivative of benzotriazole. HOBt, as a commercial product, is a white crystalline powder contains some water (~11.7% wt as the HOBt monohydrate crystal). Anhydrous HOBt is explosive. It is mainly used to suppress the racemization of single-enantiomerchiral molecules and to improve the efficiency ofpeptide synthesis. Automated peptide synthesisinvolves the condensation of the amino group of protected amino acidswith the activated ester. HOBt can be used to produce activated esters such as N-hydroxysuccinimide ester. These esters are insoluble and react with amines at ambient temperature to give amides [1]. HOBt is also used for the synthesis of amides from carboxylic acidsaside from amino acids. These substrates may not be convertible to theacyl chlorides [2]. For instance amide derivatives of ionophoric antibiotics have been prepared in this way [3].

References:
[1].  Knig W, Geiger R. EineneueMethodezurSynthese von Peptiden: Aktivierung der CarboxylgruppemitDicyclohexylcarbodiimidunterZusatz von 1‐Hydroxy‐benzotriazolen[J]. ChemischeBerichte, 1970, 103(3): 788-798.
[2].  Myers A G, Yang B H, Chen H. Transformation of Pseudoephedrine Amides into Highly Enantiomerically Enriched Aldehydes, Alcohols, and Ketones[J]. Organic Syntheses, 2000: 29-29.
[3].  owicki D, Huczyński A, Ratajczak-Sitarz M, et al. Structural and antimicrobial studies of a new N-phenylamide of monensin A complex with sodium chloride[J]. Journal of Molecular Structure, 2009, 923(1): 53-59.

文献引用

1. Gilbert T, Alsop RJ, et al. "Nanostructure of Fully Injectable Hydrazone-Thiosuccinimide Interpenetrating Polymer Network Hydrogels Assessed by Small-Angle Neutron Scattering and dSTORM Single-Molecule Fluorescence Microscopy." ACS Appl Mater Interfaces. 2017 Nov 27. PMID:29131571
2. Johansen ML, Gao Y, et al. "Quantitative Molecular Imaging with a Single Gd-Based Contrast Agent Reveals Specific Tumor Binding and Retention in Vivo." Anal Chem. 2017 Jun 6;89(11):5932-5939. PMID:28481080
3. Gilbert, Trevor. "Injectable Interpenetrating Network Hydrogels for Biomedical Applications." mcmaster university.2017.
4.Herrmann, Kelsey, et al. "Molecular Imaging of Tumors Using a Quantitative T1 Mapping Technique via Magnetic Resonance Imaging." Diagnostics 5.3 (2015): 318-332.

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at -20°C
M.Wt135.1
Cas No.2592-95-2
FormulaC6H5N3O
Solubility≥6.76mg/mL in DMSO, ≥22.4 mg/mL in EtOH with ultrasonic, ≥4.09 mg/mL in H2O with ultrasonic
Chemical Name1-hydroxybenzotriazole
SDFDownload SDF
Canonical SMILESC1=CC=C2C(=C1)N=NN2O
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

生物活性

Description HOBt是外消旋的抑制剂,用于多肽合成。
Targets racemization          
IC50            

质量控制

化学结构

HOBt (anhydrous)

相关生物数据

HOBt (anhydrous)

相关生物数据

HOBt (anhydrous)