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HG-10-102-01

现货
Catalog No.
B1262
LRRK2抑制剂
组合的产品项目
规格价格库存 数量
10mM (in 1mL DMSO)
¥ 1,290.00
Ship with 10-15 days
5mg
¥ 1,230.00
Ship with 10-15 days
10mg
¥ 2,250.00
Ship with 10-15 days
25mg
¥ 3,520.00
Ship with 10-15 days
50mg
¥ 6,320.00
Ship with 10-15 days

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Background

HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01 has shown the potent and selective inhibitor of LRRK2 with the IC50 values of 20.3nM, 153.7nM, 95.9nM and 3.2nM for wild type LRRK2, LRRK2 [A2016T], LRRK2 [G2019S+A1016T] and LRRK2 [G1019S], respectively. In addition, HG-10-102-01 has been reported to induced a dose-dependent inhibition of Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2 [G2019S] stably transfected into HEK 293 cells. Moreover, it has been demonstrated that increasing doses of HG-10-102-01 led to similar dephosphorylation of endogenous LRRK2 at Ser910 and Ser935 in HEK293 cells, mouse Swiss 3T3 cells and mouse embryonic fibroblast cells [1].

References:
[1] Choi HG1, Zhang J, Deng X, Hatcher JM, Patricelli MP, Zhao Z, Alessi DR, Gray NS. Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett. 2012 Aug 9;3(8):658-662. Epub 2012 Jun 18.

文献引用

1. Chen ZC, Zhang W, et al. "Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease." Sci Signal. 2017 Jul 18;10(488). pii: eaam6790. PMID:28720718

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt377.83
Cas No.1351758-81-0
FormulaC17H20ClN5O3
Solubility≥18.9mg/mL in DMSO
Chemical Name(E)-(4-((5-chloro-6-(methylimino)-1,6-dihydropyrimidin-2-yl)amino)-2-methoxyphenyl)(morpholino)methanone
SDFDownload SDF
Canonical SMILESC/N=C(N1)\C(Cl)=CN=C1NC2=CC(OC)=C(C(N3CCOCC3)=O)C=C2
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

化学结构

HG-10-102-01

相关生物数据

HG-10-102-01