Herbimycin A
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Herbimycin A是抗生素以及非受体酪氨酸激酶选择性抑制剂[1]。
抗生素是一种抗微生物药，用于治疗细菌感染。非受体酪氨酸激酶（nRTKs）是细胞质酶，催化磷酸基团从三磷酸核苷供体转移至蛋白质酪氨酸残基上。
Herbimycin A结合到p60v-src和p210BCR-ABL的反应性SH结构域，使其失活[1]。
在视网膜病变的早产大鼠模型中，Herbimycin A剂量依赖性地抑制毛细管形成和血管内皮细胞生长因子诱导的牛视网膜微血管内皮细胞增殖。此外，在给予氧气的大鼠以及注射Herbimycin A的眼睛中，Herbimycin A分别降低了63％和41％的视网膜前新生血管形成[2]。在暴露于热应激的老鼠中，Herbimycin A表现出耐热性，显著降低肝细胞凋亡。Herbimycin A也抑制caspase-3活化[3]。
参考文献：
[1]. Fukazawa H, Uehara Y, Murakami Y, et al. Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett, 1994, 340(3): 155-158.
[2]. McCollum GW, Rajaratnam VS, Bullard LE, et al. Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp Eye Res, 2004, 78(5): 987-995.
[3]. Sachidhanandam SB, Lu J, Low KS, et al. Herbimycin A attenuates apoptosis during heat stress in rats. Eur J Pharmacol, 2003, 474(1): 121-128.
| Physical Appearance | A yellow lyophilisate |
| Storage | Store at -20°C |
| M.Wt | 574.67 |
| Cas No. | 70563-58-5 |
| Formula | C30H42N2O9 |
| Solubility | Soluble in DMSO |
| Chemical Name | (4Z,6E,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate |
| SDF | Download SDF |
| Canonical SMILES | O=C(C(NC1=O)=C2)C([C@@H]([C@@H](C)C[C@@H]([C@@H]([C@@H](C)/C=C(C)/[C@@H]([C@H](/C=C/C=C1/C)OC)OC(N)=O)OC)OC)OC)=CC2=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
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化学结构
