hemagglutinin (332-340) [Influenza A virus]
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
流感血凝素(HA)是流感病毒表面发现的一种血凝素,它是一种抗原性糖蛋白,负责将病毒结合到被感染的细胞。HA蛋白与含唾液酸细胞的细胞膜结合,如上呼吸道细胞或红细胞[1]。
HA有两个功能。首先,它可以识别目标脊椎动物细胞,通过结合这些细胞的唾液酸受体完成识别过程。其次,一旦结合,病毒膜与宿主内体膜融合,促进病毒基因组进入靶细胞[2]。
血凝素是A型流感病毒的主要膜蛋白,对于病毒进入宿主是必须的,它是中和抗体的首要靶标。
Fig 1. Formula of Hemagglutinin
Fig 2. Structure of Hemagglutinin.
参考文献:
1. Russell RJ, Kerry PS, Stevens DJ, Steinhauer DA, Martin SR, Gamblin SJ, Skehel JJ (November 2008). "Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion". Proc. Natl. Acad. Sci. U.S.A. 105 (46): 17736–41.
2. White JM, Hoffman LR, Arevalo JH, et al. (1997). "Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.OxfordUniversity Press. pp. 80–104.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 970.12 |
Formula | C42H75N13O13 |
Synonyms | H2N-Thr-Gly-Leu-Arg-Asn-Ile-Pro-Ser-Ile-OH |
Solubility | ≥97 mg/mL in DMSO; ≥12.95 mg/mL in EtOH; ≥8.42 mg/mL in H2O |
SDF | Download SDF |
Canonical SMILES | NC(C(C)O)C(NCC(NC(CC(C)C)C(NC(CCCNC(N)=N)C(NC(CC(N)=O)C(NC(C(C)CC)C(N1C(C(NC(CO)C(NC(C(C)CC)C(O)=O)=O)=O)CCC1)=O)=O)=O)=O)=O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
质量控制和MSDS
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