HATU
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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
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SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
HATU（1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate）在肽偶联化学中用于从羧酸生成活性酯。HATU可与Hünig碱（N，N-二异丙基乙胺，DIPEA）一起使用以形成酰胺键。常用溶剂为DMF [1]。
HATU通常用于醇和胺酰化反应，例如酯和酰胺形成。这样的反应通常在两个不同的反应步骤中进行：（1）羧酸与HATU反应形成OAt-活性酯;（2）将亲核试剂如醇或胺加入到活性酯溶液中，得到酰化产物 [2,3]。
参考文献：
[1]. Carpino L A. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive[J]. Journal of the American Chemical Society, 1993, 115(10): 4397-4398.
[2]. Carpino L A, Imazumi H, El‐Faham A, et al. The uronium/guanidinium peptide coupling reagents: Finally the true uronium salts[J]. Angewandte Chemie International Edition, 2002, 41(3): 441-445.
[3]. Carpino L A, Imazumi H, Foxman B M, et al. Comparison of the Effects of 5-and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4-and 7-Isomers[J]. Organic letters, 2000, 2(15): 2253-2256.
| Storage | Desiccate at -20°C |
| M.Wt | 380.2 |
| Cas No. | 148893-10-1 |
| Formula | C10H15F6N6OP |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥16 mg/mL in DMSO |
| Chemical Name | [dimethylamino(triazolo[4,5-b]pyridin-3-yloxy)methylidene]-dimethylazanium;hexafluorophosphate |
| SDF | Download SDF |
| Canonical SMILES | CN(C)C(=[N+](C)C)ON1C2=C(C=CC=N2)N=N1.F[P-](F)(F)(F)(F)F |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
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