GSK 4112
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
IC50：2.3 μM。
GSK4112是一种rev-erbα（孤儿核受体NR1D1）激动剂，是第一种能够以相位依赖的方式重置生物钟的药剂。 Rev-erbα通过在核受体共抑制因子复合物（NCoR）和HDAC3的帮助下抑制靶基因活性来影响生物钟的精确度。 GSK4112与血红素（rev-erb的天然配体）竞争并增强共抑制因子复合物的募集，从而抑制转录。 表明通过Rev-erb的药理学调节可以提供治疗代谢疾病的新途径，尤其是由rev-erba调节的脂肪生成障碍。
临床试验：N/A。
参考文献：
[1] Daniel Grant, Lei Yin, Jon L. Collins et al. GSK4112, a small molecule chemical probe for the cell biology of the nuclear Heme receptor Rev-erbα. ACS CHEMICAL BIOLOGY 5(10):925-32.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 396.89 |
| Cas No. | 1216744-19-2 |
| Formula | C18H21ClN2O4S |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥11.9 mg/mL in DMSO |
| Chemical Name | tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate |
| SDF | Download SDF |
| Canonical SMILES | ClC1=CC=C(CN(CC2=CC=C([N+]([O-])=O)S2)CC(OC(C)(C)C)=O)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
