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Gedunin

现货
Catalog No.
B7393
天然的Hsp90抑制剂
组合的产品项目
规格价格库存 数量
1mg
¥ 1,834.00
Ship with 10-15 days

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Background

Gedunin, a naturally occurring Hsp90 inhibitor, is tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica).

Hsp90 (heat shock protein 90) is a chaperone protein stabilizes proteins against heat stress, and aids in protein degradation. Originally, this protein was isolated by extracting proteins from cells stressed by heating, dehydrating or by other means. It also stabilizes a number of proteins required for tumor growth, thereby Hsp90 inhibitors are investigated as anti-cancer drugs.

In vitro, Gedunin induces degradation of Hsp90-dependent client protein and displays anti-proliferative activity in SKBr3, CaCo-2 and MCF-7 cancer cell lines with IC50 of 3.22, 16.8 and 8.84 μM respectively1.

Gedunin treatment was shown to exhibit anti-malarial activity against P. falciparum in parasite development and [3H]-hypoxanthine uptake assays with IC50 values of 0.14 and 3.1 μM respectively 2. Using mouse model, gedunin was demonstrated to present remarkable anti-inflammatory and anti-nociceptive effects on zymosan-induced inflamed knee joints, modulation of different cell populations3.

References:
1.  Uddin SJ, Nahar L, Shilpi JA, et al. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 2007;21(8):757-761.
2.  Lee SE, Kim MR, Kim JH, et al. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;15(6-7):533-535.
3.  Conte FP, Ferraris FK, Costa TE, et al. Effect of gedunin on acute articular inflammation and hypernociception in mice. Molecules. 2015;20(2):2636-2657.

Chemical Properties

Physical AppearanceWhite solid
StorageStore at -20°C
M.Wt482.57
Cas No.2753-30-2
FormulaC28H34O7
SolubilitySoluble in DMSO
Chemical Name(1R,3aS,4aR,4bR,5S,6aS,10aR,10bS,12aS)-1-(furan-3-yl)-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-1,3,3a,4b,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate
SDFDownload SDF
Canonical SMILESO=C1O[C@H](C2=COC=C2)[C@@]3(C)[C@]4([C@]5(C)[C@@H](CC3)[C@@](C)(C=C6)[C@@H](C(C)(C)C6=O)C[C@@H]5OC(C)=O)O[C@@H]41
运输条件试用装:蓝冰运输。 其他可选规格:常温运输或根据您的要求用蓝冰运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。

质量控制

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化学结构

Gedunin