Fosinopril sodium
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Fosinopril sodium是一种有效的血管紧张素转化酶（ACE）抑制剂，IC50值为9 nM[1]。
Fosinopril是带有膦酸的第三类ACE抑制剂。该物质可用其膦酸基靶向锌离子，与ACE的活性位点结合。Fosinopril是一种口服有效的前药，可在口服后水解转化为其活性二酸化物fosinoprilat。Fosinopril的吸收率从18到41 %不等。抗酸剂可影响fosinopril的吸收，并可通过提高胃内pH降低其生物利用度。药代动力学试验显示fosinopril吸收后可完全水解为fosinoprilat。Fosinoprilat可被肾脏和肝脏缓慢清除。Fosinopril被证明可通过改善全身性和肾脏的血液动力学和降低左心室质量，从而持续地降低血压[1]。
参考文献：
[1] Shionoiri H, Naruse M, Minamisawa K, Ueda S, Himeno H, Hiroto S, Takasaki I. Fosinopril. Clinical pharmacokinetics and clinical potential. Clin Pharmacokinet. 1997 Jun;32(6):460-80.
| Storage | Store at -20°C |
| M.Wt | 585.64 |
| Cas No. | 88889-14-9 |
| Formula | C30H45NO7P·Na |
| Solubility | Soluble in DMSO |
| Chemical Name | sodium;(2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)[O-])C3CCCCC3.[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
化学结构
