Fasudil
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
对ROCK II的Ki值为0.33 μM.
脑血管痉挛发生于蛛网膜下腔出血(SHA)继发颅内动脉瘤破裂之后.钙内流阻断剂对迟发性脑血管痉挛的有效性以及鞘内给予钙拮抗剂nifedipine及其类似物nimodipine对血管痉挛的功效已从临床角度表现出.Fasudil是一类不同于钙内流阻断剂的钙拮抗剂.
体外实验:通过兔主动脉条检测Fasudil对不同激动剂引起的收缩反应的抑制效应.Fasudil 存在的情况下,5-羟色胺\前列腺素F2α\组胺\血管生成素II\去甲肾上腺素和多巴胺的浓度-反应曲线浓度依赖性地右移[1].
体内试验:狗冠状动脉内给予Fasudil能够剂量依赖性地提高冠状动脉血流量,而对平均血压或心率没有影响.冠状动脉内注射阿托品\苯海拉明或普萘洛尔并不改变体内冠状动脉扩张剂应答Fasudil [1].
临床试验:之前在SHA手术病人中的研究表明,Fasudil在抑制脑血管痉挛及随后的缺血性损伤方面等同甚至高效于nimodipine [2].
参考文献:
[1] Asano T, Suzuki T, Tsuchiya M, Satoh S, Ikegaki I, Shibuya M, Suzuki Y, Hidaka H. Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol. 1989 Dec;98(4):1091-100.
[2] Zhao J, Zhou D, Guo J, Ren Z, Zhou L, Wang S, Zhang Y, Xu B, Zhao K, Wang R, Mao Y, Xu B, Zhang X; Fasudil Aneurysmal Subarachnoid Hemorrhage Study Group. Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. Neurol Med Chir (Tokyo). 2011;51(10):679-83.
- 1. Jonard C. Valdoz, Nicholas A. Franks, et al. "Soluble ECM promotes organotypic formation in lung alveolar model." Biomaterials. 2022 Apr;283:121464. PMID: 35306229
- 2. Jihong Wang, Yong Yao, et al. "Protective effects of lycium barbarum polysaccharides on blood-retinal barrier via ROCK1 pathway in diabetic rats." Am J Transl Res 2019;11(10):6304-6315. PMID: 31737184
Storage | Store at -20°C |
M.Wt | 291.37 |
Cas No. | 103745-39-7 |
Formula | C14H17N3O2S |
Solubility | Soluble in DMSO |
Chemical Name | 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline |
SDF | Download SDF |
Canonical SMILES | O=S(C1=CC=CC2=CN=CC=C21)(N3CCCNCC3)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |