Etonogestrel
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 324.46 |
Cas No. | 54048-10-1 |
Formula | C22H28O2 |
Solubility | insoluble in H2O; ≥15.05 mg/mL in DMSO; ≥2.78 mg/mL in EtOH with gentle warming and ultrasonic |
Chemical Name | (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-11-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one |
SDF | Download SDF |
Canonical SMILES | CC[C@@]1([C@@]([C@]2([H])CCC3=CC(CC[C@]3([H])[C@@]42[H])=O)([H])CC[C@@]1(O)C#C)CC4=C |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
细胞实验[1]: | |
细胞系 |
人子宫内膜间质细胞 |
溶解方法 |
在DMSO中的溶解度大于10 mM。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
反应条件 |
7天,100 nM |
应用 |
Etonogestrel是去氧孕烯前体药物的活性代谢产物。在人子宫内膜间质细胞中,Etonogestrel能够激活GR信号,诱导FKBP51 mRNA和蛋白的表达。 |
动物实验[2]: | |
动物模型 |
8-12周龄的雌性C57BL/6小鼠 |
剂量 |
切除卵巢的小鼠皮下注射100 ng 17β雌二醇,一天3次,静养3天,然后将四分之一的含有Etonogestrel的标准Implanon棒皮下插入动物的背部。检查长期(长达45天)暴露于Etonogestrel对小鼠子宫内膜的影响。 |
应用 |
在小鼠蜕膜角中有大的血管形成,第5天时组织完整性受到干扰,10天时发生了本质的破坏。这个过程一直持续到25天,这时开始再生新的表皮细胞。45天时组织恢复到蜕化前的状态,但是还有大量的内腔上皮弯曲。 |
注意事项 |
请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同。这是由实验系统的误差引起的,属于正常现象。 |
References: [1]. Kayisli O G, Kayisli U A, Basar M, et al. Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive-Associated Abnormal Uterine Bleeding[J]. PloS one, 2015, 10(10): e0137855. [2]. Morison N B, Zhang J, Tu’uhevaha J, et al. The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women[J]. Reproduction, 2007, 133(1): 309-321. |
质量控制和MSDS
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