Etomoxir
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Storage | Store at -20°C |
M.Wt | 326.82 |
Cas No. | 124083-20-1 |
Formula | C17H23ClO4 |
Synonyms | R-(+)-Etomoxir,Etomoxir |
Solubility | ≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming |
Chemical Name | ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate |
SDF | Download SDF |
Canonical SMILES | CCOC(=O)C1(CO1)CCCCCCOC2=CC=C(C=C2)Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
细胞实验[1]: | |
细胞系 |
大鼠心脏H9c2成肌细胞 |
溶解方法 |
该化合物可溶于DMSO。为了获得更高的浓度,可以将离心管在37℃加热10分钟和/或在超声波浴中震荡一段时间。原液可以在-20℃以下储存几个月。 |
反应条件 |
1-80 μM; 2 h |
应用 |
在大鼠心脏H9c2成肌细胞中,Etomoxir浓度依赖性地减少[1-14C]油酸掺入磷脂酰甘油(PtdGro)和心磷脂(CL)。相比之下,etomoxir增加[1,3-3H]甘油掺入心磷脂(CL)。 |
动物实验[2]: | |
动物模型 |
实验性自身免疫性脑脊髓炎(EAE)小鼠模型 |
剂量 |
15 mg/kg; 腹腔注射; 第8天和第15天 |
应用 |
在实验性自身免疫性脑脊髓炎(EAE)小鼠中,Etomoxir降低了疾病严重程度和炎症反应。Etomoxir治疗小鼠减少了中枢神经系统(CNS)中的的免疫细胞浸润,仅存在少量巨噬细胞,活化的小胶质细胞或T细胞。Etomoxir还减少CNS中炎症和脱髓鞘。 |
注意事项 |
请测试所有化合物在室内的溶解度,实际溶解度和理论值可能略有不同,这是由实验系统的误差引起的,属于正常现象。 |
References: [1]. Xu FY1, Taylor WA, Hurd JA, et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003 Feb;44(2):415-23. Epub 2002 Nov 4. [2] Shriver LP1, Manchester M. Inhibition of fatty acid metabolism ameliorates disease activity in an animal model of multiple sclerosis. Sci Rep. 2011;1:79. |
质量控制和MSDS
- 批次: