Dynamin inhibitory peptide
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
动力素抑制肽是GTPase动力素的多肽抑制剂，氨基酸序列为Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro。
动力素是一个100 kDa的较大的GTP酶，其功能是释放来自于高尔基体和细胞质膜新生囊泡。动力素在细胞器的分裂、胞质分裂和微生物病原体抗性等过程中发挥重要作用。
动力素多肽抑制剂竞争性阻断动力素与amphiphysin蛋白的结合，当胞内给药时，可以防止内吞作用。在表达GABAA受体的神经元中，可以减少GABA受体的内化和增加mISPC的幅度和频率。
Figure1 Formula of Dynamin Inhibitory Peptide
参考文献：
1. McNiven, M. A., Cao, H., Pitts, K. R. & Yoon, Y. (2000) Trends Biochem. Sci. 25, 115–120.
2. Hinshaw, J. E. (2000) Annu. Rev. Cell Dev. Biol 16, 483–519.
3. Thoms S, Erdmann R (Oct 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation.". FEBS J 272 (20): 5169–81.
4. Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419-25.
5. Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972-7.
6. Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302-7.
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 1121.26 |
| Cas No. | 251634-21-6 |
| Formula | C47H80N18O14 |
| Synonyms | Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro |
| Solubility | ≥112.1 mg/mL in DMSO; ≥23.6 mg/mL in EtOH; ≥9.4 mg/mL in H2O |
| Chemical Name | Dynamin inhibitory peptide |
| SDF | Download SDF |
| Canonical SMILES | CC(C)C(C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)N2CCCC2C(=O)NC(CC(=O)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)N3CCCC3C(=O)O)NC(=O)C(CCC(=O)N)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
