Dutasteride
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Dutasteride（适尿通）是可用于治疗良性前列腺增生（BPH）的双5-alpha-还原酶抑制剂。
Dutasteride在LNCaP细胞中可抑制99%的3H-睾酮向3H-DHT的转化。Dutasteride也可强效抑制LNCaP细胞的生长、增殖和活力。Dutasteride处理48 h可剂量依赖地提高caspase 7和caspase 8的酶活，为LNCaP细胞中dutasteride激活凋亡和存活途径提供借鉴和确证[1]。
在体内，可同时抑制5αR1/5αR2的dutasteride在C57BL/6 TRAMP x FVB小鼠中可有效阻断前列腺癌的发生和发展[2]。
参考文献：
[1] Schmidt LJ1, Murillo H, Tindall DJ. Gene expression in prostate cancer cells treated with the dual 5 alpha-reductase inhibitor dutasteride. J Androl. 2004 Nov-Dec;25(6):944-53.
[2] Opoku-Acheampong AB1, Unis D, Henningson JN, Beck AP, Lindshield BL. Preventive and therapeutic efficacy of finasteride and dutasteride in TRAMP mice. PLoS One. 2013 Oct 18;8(10):e77738. doi: 10.1371/journal.pone.0077738. eCollection 2013.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 528.53 |
| Cas No. | 164656-23-9 |
| Formula | C27H30F6N2O2 |
| Solubility | ≥26.43 mg/mL in DMSO; insoluble in EtOH; ≥13.75 mg/mL in H2O with ultrasonic |
| Chemical Name | (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
- 批次:
化学结构
