DiscoveryProbe™ Epigenetics Compound Library
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
- 1. Anna M Schreiber, Yanjie Li, et al. "Selected Histone Deacetylase Inhibitors Reverse the Frataxin Transcriptional Defect in a Novel Friedreich’s Ataxia Induced Pluripotent Stem Cell-Derived Neuronal Reporter System." Front Neurosci. 2022 Feb 23;16:836476. PMID: 35281493
- 2. E Alexis Flores-Padilla, K Eurídice Juárez-Mercado, et al. "Chemoinformatic Characterization of Synthetic Screening Libraries Focused on Epigenetic Targets." Mol Inform. 2022 Jun;41(6):e2100285. PMID: 34931466
- 3. Diana L Prado-Romero, José L Medina-Franco. "Advances in the Exploration of the Epigenetic Relevant Chemical Space." ACS Omega. 2021 Aug 23;6(35):22478-22486. PMID: 34514220
- 4. Jennifer Zhang, Oscar Hou-In Chou, et al. "Application of Patient-Specific iPSCs for Modelling and Treatment of X-Linked Cardiomyopathies." Int J Mol Sci. 2021 Jul 29;22(15):8132. PMID: 34360897
| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles | |
| A3692 | OTX-015 | BRD inhibitor | Bromodomain | 202590-98-5 | CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C | |
| A4093 | ITF2357 (Givinostat) | HDAC inhibitor | HDAC | 732302-99-7 | CCN(CC)CC1=CC2=C(C=C(COC(NC3=CC=C(C(NO)=O)C=C3)=O)C=C2)C=C1.O.Cl | |
| A4138 | Tofacitinib (CP-690550,Tasocitinib) | Janus kinase inhibitor | JAK | 477600-75-2 | CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N | |
| A4166 | EPZ5676 | DOT1L inhibitor,potent and SAM competitive | Histone Methyltransferase | 1380288-87-8 | CC(C)N(CC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C | |
| A8708 | Sephin1 | Selective PPP1R15A inhibitor | Protein Ser/Thr Phosphatases | 13098-73-2 | ClC1=CC=CC=C1/C=N/NC(N)=N | |
| A8712 | MCB-613 | stimulator of steroid receptor coactivator (SRC) | Histone Acetyltransferases | 1162656-22-5 | O=C(/C(CN(CC)C/1)=C/C2=CC=CN=C2)C1=C\C3=CN=CC=C3 | |
| B1499 | RVX-208 | Potent BET bromodomain inhibitor | Bromodomain | 1044870-39-4 | CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(C=C(C=C3N2)OC)OC | |
| B4891 | ML324 | JMJD2 demethylase inhibitor, potent and cell-permeable | Histone Demethylases | 1222800-79-4 | OC1=CC(C2=CC=C(C(NCCCN(C)C)=C)C=C2)=CC3=CC=CN=C31 | |
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下载 APExBIO化合物库使用说明 下载 DiscoveryProbe™ Epigenetics Compound Library（SDF & XLSX） |
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| Form | Pre-dissolved DMSO solutions | Stability | Solution: -20°C for 12 months, -80°C for 24 months |
| Packaging | 96-well DeepWell format with peelable foil seal and EVA cap (100 μL/well, 10 mM DMSO). 96-well rack with Matrix 2D Barcoded ScrewTop Storage tubes (250 μL or 100 μL/well, 10 mM DMSO). |
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| Shipping Condition | Evaluation sample solution: ship with blue ice All other available size: ship with RT, or blue ice upon request |
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-- Available in stock with overnight delivery and free shipping over $500.
-- Cost-effective and competitive price to save your budget.
-- Potent, selective and cell-permeable in inhibiting or activating target molecules.
-- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
-- Detailed files describing potency, selectivity and applications etc.
-- Supported by published data from top peer-reviewed journals.
-- Guaranteed high quality with NMR and HPLC validation.
