Deferasirox
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Deferasirox是铁离子螯合剂[1].
铁离子螯合剂是可溶性的铁\钠和螯合剂的复合体,用于使铁溶于水.铁离子螯合剂最初开发用于临床治疗铁超载[1].
Deferasirox是口服的铁离子螯合剂,用于治疗铁超载疾病.在DMS-53肺癌和SK-N-MC神经上皮瘤细胞系中,Deferasirox能够抑制细胞增殖.Deferasirox抑制人转铁蛋白吸收铁离子,动员细胞59Fe [1].在两种食管癌细胞系OE33和OE19中,Deferasirox与标准化疗药联合使用抑制细胞活力和增殖[2].
在DMS-53肺癌异种移植裸鼠中,Deferasirox 抑制肿瘤生长.并且,Deferasirox提高裂解caspase-3\裂解聚ADP核糖聚合酶1\细胞周期蛋白依赖激酶抑制剂p21CIP1/WAF1以及转移抑制蛋白N-myc下游调节基因1的表达,同时降低周期蛋白D1,表明Deferasirox是有效的抗肿瘤剂[1].在人类异种移植模型中,Deferasirox显著抑制肿瘤生长,这与铁离子水平的降低相关[2].
参考文献：
[1]. Lui GY, Obeidy P, Ford SJ, et al. The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action. Mol Pharmacol, 2013, 83(1): 179-190.
[2]. Ford SJ, Obeidy P, Lovejoy DB, et al. Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo. Br J Pharmacol, 2013, 168(6): 1316-1328.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 373.37 |
| Cas No. | 201530-41-8 |
| Formula | C21H15N3O4 |
| Solubility | insoluble in H2O; ≥37.28 mg/mL in DMSO; ≥2.94 mg/mL in EtOH with ultrasonic |
| Chemical Name | 4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid |
| SDF | Download SDF |
| Canonical SMILES | O=C(O)C1=CC=C(N2C(C3=CC=CC=C3O)=NC(C4=CC=CC=C4O)=N2)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
质量控制和MSDS
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化学结构
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